Reactome | CNIH1 binds TFGA and AREG precursors

CNIH1 binds TFGA and AREG precursors

Stable Identifier

R-HSA-5694445

Type

Reaction [binding]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        Cargo concentration in the ER (Homo sapiens)
        
        CNIH1 binds TFGA and AREG precursors (Homo sapiens)

General

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CNIH1, also known as ERV14, is a member of the ERV family of proteins that act as cargo receptors for ER-to-ERGIC trafficking (reviewed in Dancourt and Barlowe, 2010). CNIH1 preferentially interacts with transmembrane proteins like the precursor forms of TFGA and AREG, and mediates their packaging into COPII vesicles by interacting with components of the COPII coat (Castro et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
20533886	Protein sorting receptors in the early secretory pathway Dancourt, J, Barlowe, C	Annu. Rev. Biochem.	2010
17607000	Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells Derynck, R, Castro, CP, Nakagawa, T, Piscopo, D	J. Cell. Sci.	2007