CNIH1 binds TFGA and AREG precursors

Stable Identifier
R-HSA-5694445
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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CNIH1, also known as ERV14, is a member of the ERV family of proteins that act as cargo receptors for ER-to-ERGIC trafficking (reviewed in Dancourt and Barlowe, 2010). CNIH1 preferentially interacts with transmembrane proteins like the precursor forms of TFGA and AREG, and mediates their packaging into COPII vesicles by interacting with components of the COPII coat (Castro et al, 2007).

Literature References
PubMed ID Title Journal Year
17607000 Cornichon regulates transport and secretion of TGFalpha-related proteins in metazoan cells

Castro, CP, Piscopo, D, Nakagawa, T, Derynck, R

J. Cell. Sci. 2007
20533886 Protein sorting receptors in the early secretory pathway

Dancourt, J, Barlowe, C

Annu. Rev. Biochem. 2010
Participants
Participant Of
Orthologous Events
Authored
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Created