AMT transfers NH2CH2 from GCSH:SAMDLL to THF

Stable Identifier
R-HSA-5693977
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
AMT degrades GCSH:SAMDLL to GCSH:DHLL
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The major degradative pathway for the amino acid glycine is via the glycine cleavage system. In the second reaction in this system, the decarboxylated moiety from glycine decarboxylation attached to H protein (GCSH:SAMDLL) is further degraded by mitochondrial aminomethyltransferase (AMT, GCST, T protein) to ammonia (NH3) and GCSH with reduced lipoate. Tetrahydrofolate (THF) is required for this reaction and accepts the methyl group to form 5,10MTHF (Fujiwara et al. 1984).

Literature References
Participants
Participates
Catalyst Activity

aminomethyltransferase activity of AMT [mitochondrial matrix]

Orthologous Events
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