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BCKDK [mitochondrial matrix]
Stable Identifier
R-HSA-5693129
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial ecNumber2.7.11.4/ecNumber, BCKD_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Branched-chain amino acid catabolism (Homo sapiens)
BCKDK phosphorylates BCKDH (Homo sapiens)
BCKDK [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14874 BCKDK
Gene Names
BCKDK
Chain
transit peptide:1-30, chain:31-412
Reference Genes
BioGPS Gene:10295 BCKDK
COSMIC (genes):BCKDK BCKDK
CTD Gene:10295 BCKDK
dbSNP Gene:10295 BCKDK
ENSEMBL:ENSG00000103507.14 BCKDK
HGNC:16902 BCKDK
KEGG Gene (Homo sapiens):10295 BCKDK
Monarch:10295 BCKDK
NCBI Gene:10295 BCKDK
OMIM:614901 BCKDK
UCSC:O14874 BCKDK
Reference Transcript
RefSeq:NM_001271926.1 BCKDK
RefSeq:NM_005881.3 BCKDK
RefSeq:NM_001122957.2 BCKDK
Other Identifiers
10295
11719705_a_at
11743293_a_at
11743294_x_at
11744767_x_at
16818165
202030_PM_at
202030_at
32828_at
3656830
3656833
3656834
3656835
3656836
3656837
3656838
3656840
3656842
3656844
3656845
3656846
3656847
3656848
3656849
3656850
3656851
3656852
3656853
3656854
7995040
A_14_P123905
A_23_P365149
A_23_P3823
GE54207
GO:0000166
GO:0003824
GO:0004672
GO:0004674
GO:0004740
GO:0005515
GO:0005524
GO:0005739
GO:0005759
GO:0005947
GO:0005975
GO:0006468
GO:0006520
GO:0009063
GO:0009083
GO:0010906
GO:0016301
GO:0016310
GO:0016740
GO:0016772
GO:0036211
GO:0043226
GO:0045763
GO:0047323
GO:0140096
HMNXSV003033146
ILMN_1693394
PH_hs_0001785
TC16000370.hg
g5031608_3p_at
Inferred To
BCKDK [mitochondrial matrix]
(Bos taurus)
BCKDK [mitochondrial matrix]
(Canis familiaris)
BCKDK [mitochondrial matrix]
(Danio rerio)
BCKDK [mitochondrial matrix]
(Sus scrofa)
Bckdk [mitochondrial matrix]
(Mus musculus)
Bckdk [mitochondrial matrix]
(Rattus norvegicus)
bckdk [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
RefSeq
NP_001258855.1
,
NP_005872.2
,
NP_001116429.1
Guide to Pharmacology - Targets
1939
OpenTargets
ENSG00000103507
GeneCards
O14874
HPA
ENSG00000103507-BCKDK
Ensembl
ENST00000219794
,
ENST00000394950
,
ENSP00000378404
,
ENSP00000219794
,
ENST00000394951
,
ENSP00000378405
,
ENSP00000287507
,
ENSG00000103507
,
ENST00000287507
PRO
O14874
Pharos - Targets
O14874
Orphanet
21447
HMDB Protein
HMDBP01493
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P25631 YCU1
0.556
3
UniProt:P02549 SPTA1
1
SPTA1 [cytosol]
(R-HSA-391563)
0.556
3
UniProt:P0DTD1-PRO_0000449629 REP
0.527
2
UniProt:O15182 CETN3
0.527
2
UniProt:P41208 CETN2
3
polySUMO2,3-CETN2 [nucleoplasm]
(R-HSA-4570486)
CETN2 [nucleoplasm]
(R-HSA-4570490)
CETN2 [cytosol]
(R-HSA-380298)
0.527
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.508
2
UniProt:Q9WMX2-PRO_0000037548
0.508
2
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