SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
MAPK6 and MAPKAPK5 directly phosphorylate the septin regulating proteins CDC42EP2, 3 and 5 (also known as BORG1, 2 and 3 for Binders of Rho GTPases) in vitro. BORG/CDC42EP proteins interact with septins through the septin GTPase domain and inhibit filament formation. This effect of the BORG proteins on septin filamentation is itself inhibited by CDC42 (Jouberty et al, 2001; reviewed in Spiliotis and Nelson, 2006). The interaction between SEPT7 and the CDC42EP proteins may facilitate their recruitment to the ternary MAPK6:MAPKAPK5:SEPT7 complex for phosphorylation, although the significance of this phosphorylation is not yet clear (Brand et al, 2012).
Literature References
PubMed ID Title Journal Year
11584266 Borg proteins control septin organization and are negatively regulated by Cdc42

Perlungher, RR, Joberty, G, Macara, IG, Kinoshita, M, Sheffield, PJ, Haystead, T, Noda, M

Nat. Cell Biol. 2001
16371649 Here come the septins: novel polymers that coordinate intracellular functions and organization

Spiliotis, ET, Nelson, WJ

J. Cell. Sci. 2006
22508986 The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology

Schumacher, S, Brand, F, Kant, S, Meloche, S, Kotlyarov, A, Gaestel, M, Menon, MB, Turgeon, B, Simon, R, Britsch, S

Mol. Cell. Biol. 2012
Catalyst Activity

protein serine/threonine kinase activity of SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 [cytosol]

Orthologous Events
Cite Us!