Reactome | SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs

SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs

Stable Identifier

R-HSA-5692775

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs

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MAPK6 and MAPKAPK5 directly phosphorylate the septin regulating proteins CDC42EP2, 3 and 5 (also known as BORG1, 2 and 3 for Binders of Rho GTPases) in vitro. BORG/CDC42EP proteins interact with septins through the septin GTPase domain and inhibit filament formation. This effect of the BORG proteins on septin filamentation is itself inhibited by CDC42 (Jouberty et al, 2001; reviewed in Spiliotis and Nelson, 2006). The interaction between SEPT7 and the CDC42EP proteins may facilitate their recruitment to the ternary MAPK6:MAPKAPK5:SEPT7 complex for phosphorylation, although the significance of this phosphorylation is not yet clear (Brand et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
11584266	Borg proteins control septin organization and are negatively regulated by Cdc42 Joberty, G, Perlungher, RR, Sheffield, PJ, Kinoshita, M, Noda, M, Haystead, T, Macara, IG	Nat. Cell Biol.	2001
16371649	Here come the septins: novel polymers that coordinate intracellular functions and organization Spiliotis, ET, Nelson, WJ	J. Cell. Sci.	2006
22508986	The extracellular signal-regulated kinase 3 (mitogen-activated protein kinase 6 [MAPK6])-MAPK-activated protein kinase 5 signaling complex regulates septin function and dendrite morphology Brand, F, Schumacher, S, Kant, S, Menon, MB, Simon, R, Turgeon, B, Britsch, S, Meloche, S, Gaestel, M, Kotlyarov, A	Mol. Cell. Biol.	2012