Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
OX40 [plasma membrane]
Stable Identifier
R-HSA-5692210
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
TNFRSF4, Tumor necrosis factor receptor superfamily member 4, CD134
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
TNFs bind their physiological receptors (Homo sapiens)
OX40L binds OX40 (Homo sapiens)
3xOX40:OX40L trimer [plasma membrane] (Homo sapiens)
OX40 [plasma membrane] (Homo sapiens)
OX40 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43489 TNFRSF4
Gene Names
TNFRSF4, TXGP1L
Chain
signal peptide:1-28, chain:29-277
Reference Genes
BioGPS Gene:7293 TNFRSF4
COSMIC (genes):TNFRSF4 TNFRSF4
CTD Gene:7293 TNFRSF4
dbSNP Gene:7293 TNFRSF4
ENSEMBL:ENSG00000186827 TNFRSF4
HGNC:11918 TNFRSF4
Monarch:7293 TNFRSF4
NCBI Gene:7293 TNFRSF4
OMIM:600315 TNFRSF4
UCSC:P43489 TNFRSF4
Reference Transcript
RefSeq:XM_017002232.1 TNFRSF4
RefSeq:NM_003327.3 TNFRSF4
Other Identifiers
11727600_a_at
16680085
214228_3p_x_at
214228_PM_x_at
214228_x_at
2391173
2391174
2391175
2391176
2391177
2391178
2391180
2391181
2391182
2391183
2391184
2391185
2391186
2391187
34916_s_at
7293
7911413
A_32_P26092
A_33_P3286157
GO:0001618
GO:0002376
GO:0002639
GO:0005031
GO:0005515
GO:0005886
GO:0006355
GO:0006954
GO:0006955
GO:0009897
GO:0009986
GO:0016020
GO:0030890
GO:0033209
GO:0042098
GO:0043433
GO:0045892
GO:0046718
GO:0060089
HMNXSV003048489
Hs.129780.1.S1_3p_a_at
Hs.129780.1.S1_3p_at
Hs.129780.1.S1_3p_x_at
ILMN_1710204
ILMN_2112256
PH_hs_0007601
TC01002086.hg
Participates
as a component of
3xOX40:OX40L trimer [plasma membrane] (Homo sapiens)
as an input of
OX40L binds OX40 (Homo sapiens)
Inferred To
Tnfrsf4 [plasma membrane]
(Mus musculus)
Tnfrsf4 [plasma membrane]
(Rattus norvegicus)
OX40 [plasma membrane]
(Gallus gallus)
TNFRSF4 [plasma membrane]
(Bos taurus)
TNFRSF4 [plasma membrane]
(Canis familiaris)
TNFRSF4 [plasma membrane]
(Sus scrofa)
tnfrsf4 [plasma membrane]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
1873
ENSEMBL
ENST00000379236
,
ENSP00000368538
OpenTargets
ENSG00000186827
HPA
ENSG00000186827-TNFRSF4
PRO
P43489
Pharos - Targets
P43489
GlyGen
P43489
Orphanet
TNFRSF4
PDB
2HEY
,
6OKN
,
2HEV
,
1D0A
,
8AG1
,
6OGX
,
7YK4
,
6OKM
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P23510 TNFSF4
1
TNFSF4 [plasma membrane]
(R-HSA-5666995)
0.558
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text