Reactome | TNFSF4 [plasma membrane]

TNFSF4 [plasma membrane]

Stable Identifier

R-HSA-5666995

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Tumor necrosis factor ligand superfamily member 4, TNFL4_HUMAN, OX40L, CD252

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - TNFR2 non-canonical NF-kB pathway (Homo sapiens)
    - TNFs bind their physiological receptors (Homo sapiens)
      - OX40L binds OX40 (Homo sapiens)
        
        3xOX40:OX40L trimer [plasma membrane] (Homo sapiens)
        
        OX40L trimer [plasma membrane] (Homo sapiens)
        
        TNFSF4 [plasma membrane] (Homo sapiens)
        
        OX40L trimer [plasma membrane] (Homo sapiens)
        
        TNFSF4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P23510 TNFSF4

Gene Names

TNFSF4, TXGP1

Chain

chain:1-183

Reference Genes

BioGPS Gene:7292 TNFSF4

COSMIC (genes):TNFSF4 TNFSF4

CTD Gene:7292 TNFSF4

dbSNP Gene:7292 TNFSF4

ENSEMBL:ENSG00000117586 TNFSF4

ENSEMBL_homo_sapiens_GENE:ENSG00000117586.11 TNFSF4

HGNC:11934 TNFSF4

KEGG Gene (Homo sapiens):7292 TNFSF4

Monarch:7292 TNFSF4

NCBI Gene:7292 TNFSF4

OMIM:603594 TNFSF4

UCSC:P23510 TNFSF4

Reference Transcript

Other Identifiers

11731896_a_at

11753073_a_at

16696425

207426_PM_s_at

207426_s_at

2444284

2444285

2444286

2444288

2444290

2444291

2444292

2444293

2444294

2444295

32319_at

7292

7922343

A_23_P126836

D90224_at

GE79215

GO:0001819

GO:0002215

GO:0002376

GO:0002526

GO:0002639

GO:0002726

GO:0002819

GO:0002830

GO:0002891

GO:0005102

GO:0005125

GO:0005164

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0006310

GO:0006351

GO:0006355

GO:0006954

GO:0006955

GO:0007154

GO:0007155

GO:0007165

GO:0008284

GO:0009615

GO:0009986

GO:0016020

GO:0023052

GO:0030154

GO:0032689

GO:0032700

GO:0032722

GO:0032729

GO:0032733

GO:0032735

GO:0032736

GO:0032753

GO:0032755

GO:0032813

GO:0035709

GO:0035712

GO:0035713

GO:0042102

GO:0043372

GO:0043382

GO:0043433

GO:0045590

GO:0045626

GO:0045630

GO:0045892

GO:0046641

GO:0048018

GO:0048856

GO:0050727

GO:0050729

GO:0050871

GO:0071222

GO:0071380

GO:0098542

GO:0098772

GO:1900281

GO:2000572

HMNXSV003056291

ILMN_1746175

ILMN_2089875

PH_hs_0010714

TC01003525.hg

g4507602_3p_a_at

Participates

as a component of

OX40L trimer [plasma membrane] (Homo sapiens)

Inferred To

TNLG2B [plasma membrane] (Canis familiaris)

Tnfsf4 [plasma membrane] (Mus musculus)

Tnfsf4 [plasma membrane] (Rattus norvegicus)

TNFSF4 [plasma membrane] (Bos taurus)

TNFSF4 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_003317.1, NP_001284491.1

OpenTargets

ENSG00000117586

HPA

ENSG00000117586-TNFSF4

GeneCards

P23510

Ensembl

ENSP00000356691, ENSP00000281834, ENST00000281834, ENST00000367718, ENSG00000117586

PRO

P23510

Pharos - Targets

P23510

Orphanet

22425

PDB

2HEV

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P43489 TNFRSF4	1	OX40 [plasma membrane] (R-HSA-5692210)	0.558	2

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