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UVSSA [nucleoplasm]
Stable Identifier
R-HSA-5688915
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
UV-stimulated scaffold protein A, KIAA1530
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Transcription-Coupled Nucleotide Excision Repair (TC-NER) (Homo sapiens)
Dual incision in TC-NER (Homo sapiens)
3' incision by ERCC5 (XPG) in TC-NER (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Binding of ERCC1:ERCC4 (ERCC1:XPF) to pre-incision complex in TC-NER (Homo sapiens)
TC-NER incision complex [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
DNA polymerases delta, epsilon or kappa bind the TC-NER site (Homo sapiens)
TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
ERCC2-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
ERCC3-facilitated RNA Pol II backtracking in TC-NER (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Partially open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
ERCC5 and RPA bind TC-NER site (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:RPA:ERCC5:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER pre-incision complex:Open bubble damaged DNA template:trimmed nascent mRNA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Formation of TC-NER Pre-Incision Complex (Homo sapiens)
Assembly of the pre-incision complex in TC-NER (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 deubiquitinates ERCC6 (Homo sapiens)
TC-NER pre-incision complex [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1:UVSSA:USP7:XAB2 complex:XPA:TCEA1:HMGN1:EP300 [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Gap-filling DNA repair synthesis and ligation in TC-NER (Homo sapiens)
Ligation of newly synthesized repair patch to incised DNA in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER (Homo sapiens)
TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
Recovery of RNA synthesis after TC-NER (Homo sapiens)
TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
UVSSA [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q2YD98 UVSSA
Gene Names
UVSSA, KIAA1530
Chain
chain:1-709
Reference Genes
BioGPS Gene:57654 UVSSA
COSMIC (genes):UVSSA UVSSA
CTD Gene:57654 UVSSA
dbSNP Gene:57654 UVSSA
ENSEMBL:ENSG00000163945 UVSSA
HGNC:29304 UVSSA
KEGG:hsa:57654 UVSSA
Monarch:57654 UVSSA
NCBI Gene:57654 UVSSA
OMIM:614632 UVSSA
UCSC:Q2YD98 UVSSA
Reference Transcript
RefSeq:NM_001317935.1 UVSSA
RefSeq:XM_017008492.1 UVSSA
RefSeq:XM_017008493.1 UVSSA
RefSeq:XM_017008491.1 UVSSA
RefSeq:XM_017008490.1 UVSSA
RefSeq:NM_020894.3 UVSSA
RefSeq:XM_017008494.1 UVSSA
RefSeq:NM_001317934.1 UVSSA
Other Identifiers
11724140_a_at
11749768_a_at
11756484_a_at
11758690_s_at
1555107_PM_a_at
1555107_a_at
16963949
16963981
228318_PM_s_at
228318_s_at
233893_PM_s_at
233893_s_at
234761_PM_at
234761_at
241408_PM_at
241408_at
2714731
2714732
2714733
2714734
2714735
2714736
2714740
2714742
2714747
2714748
2714749
2714750
2714751
2714752
2714753
2714754
2714764
2714770
2714771
2714777
2714778
2714779
2714780
2714781
2714793
2714795
2714796
2714798
2714799
2714800
2714801
2714802
2714803
2714804
2714805
2714806
2714807
2714808
2714809
2714810
2714815
2714817
2714819
2714820
2714821
2714822
2714823
2714824
2714825
43974_at
57654
60515_r_at
8093476
8093494
A_14_P104978
A_23_P431330
A_32_P319880
A_33_P3287113
A_33_P3422233
A_33_P3422240
GE523155
GO:0000993
GO:0005515
GO:0005654
GO:0005694
GO:0006281
GO:0006283
GO:0009411
GO:0016567
GO:0043226
HMNXSV003015281
HMNXSV003019549
HMNXSV003045005
Hs.191268.0.A1_3p_a_at
Hs.257634.0.S1_3p_at
Hs.26410.0.A1_3p_s_at
Hs2.191268.1.S1_3p_s_at
ILMN_1721986
ILMN_1728490
ILMN_1729827
ILMN_1810225
ILMN_2140700
PH_hs_0002326
PH_hs_0024319
TC04000024.hg
TC04000027.hg
TC04001854.hg
Participates
as a component of
UVSSA:USP7 [nucleoplasm] (Homo sapiens)
Inferred To
uvssa [nucleoplasm]
(Danio rerio)
uvssa [nucleoplasm]
(Xenopus tropicalis)
Uvssa [nucleoplasm]
(Mus musculus)
Uvssa [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of UVSSA [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of UVSSA [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of UVSSA [nucleoplasm]
(Plasmodium falciparum)
Ghost homologue of UVSSA [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of UVSSA [nucleoplasm]
(Schizosaccharomyces pombe)
UVSSA [nucleoplasm]
(Bos taurus)
UVSSA [nucleoplasm]
(Canis familiaris)
UVSSA [nucleoplasm]
(Gallus gallus)
UVSSA [nucleoplasm]
(Sus scrofa)
uvs-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000163945
ENSEMBL
ENSP00000503948
,
ENST00000511216
,
ENST00000679192
,
ENST00000512728
,
ENSP00000427701
,
ENSP00000421741
,
ENST00000389851
,
ENST00000507531
,
ENSG00000163945
,
ENST00000677286
,
ENSP00000504544
,
ENSP00000374501
,
ENSP00000425130
HPA
ENSG00000163945-UVSSA
GeneCards
UVSSA
PRO
Q2YD98
Pharos - Targets
Q2YD98
Orphanet
UVSSA
PDB
7OO3
,
8B3D
,
7OOP
,
8B3G
,
7OPC
,
8QH5
,
7OPD
,
5XV8
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