MAPK6 is degraded by the 26S proteasome

Stable Identifier
Reaction [omitted]
Homo sapiens
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MAPK6 is a short-lived protein with a half-life of 30 minutes in proliferating cells. Turnover is promoted by the conjugation of ubiquitin to the free amino terminal by an unknown ligase and subsequent degradation by the 26 S proteasome (Coulombe et al, 2003; Coulombe et al, 2004). Ubiquitination and degradation of MAPK6 may also occur in the nucleus as well as the cytosol.

Literature References
PubMed ID Title Journal Year
15226418 N-Terminal ubiquitination of extracellular signal-regulated kinase 3 and p21 directs their degradation by the proteasome

Meloche, S, Rodier, G, Coulombe, P, Bonneil, E, Thibault, P

Mol. Cell. Biol. 2004
12808096 Rapid turnover of extracellular signal-regulated kinase 3 by the ubiquitin-proteasome pathway defines a novel paradigm of mitogen-activated protein kinase regulation during cellular differentiation

Meloche, S, Rodier, G, Coulombe, P, Pelletier, S, Pellerin, J

Mol. Cell. Biol. 2003
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Orthologous Events
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