MAPK4,6 translocate to the cytoplasm

Stable Identifier
R-HSA-5687109
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Despite differences in their overall cellular distribution (MAPK6 is found in both the nucleus and the cytosol, while MAPK4 is predominantly found in the cytosol), both MAPK4 and 6 shuttle between the cytosol and the nucleus. Nuclear import of both proteins occurs through an active temperature sensitive pathway, while nuclear export depends on XPO1 (Aberg et al, 2006; Julien et al, 2003).

Literature References
PubMed ID Title Journal Year
12915405 Nuclear export of ERK3 by a CRM1-dependent mechanism regulates its inhibitory action on cell cycle progression

Julien, C, Coulombe, P, Meloche, S

J. Biol. Chem. 2003
16971392 Regulation of MAPK-activated protein kinase 5 activity and subcellular localization by the atypical MAPK ERK4/MAPK4

Aberg, E, Perander, M, Johansen, B, Julien, C, Meloche, S, Keyse, SM, Seternes, OM

J. Biol. Chem. 2006
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