Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2

Stable Identifier
R-HSA-5686469
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
nucleoplasm
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Summation

Based on studies in yeast, D-loop cleavage by MUS81 in complex with EME1 or EME2 always produces crossovers between sister chromatids (Osman et al. 2003). The identity of the DNA polymerase(s) and ligase(s) that complete DNA repair synthesis and ligation after MUS81:EME1 or MUS81:EME2 cleavage of D-loops has not been determined.

Literature References
PubMed ID Title Journal Year
14527420 Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis

Osman, F, Dixon, J, Doe, CL, Whitby, MC

Mol. Cell 2003
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Bos taurus)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Canis familiaris)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Gallus gallus)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Sus scrofa)
Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Xenopus tropicalis)
Authored
Matthews, L  (2003-11-23)
Reviewed
Borowiec, JA  (2015-06-12)