Reactome | Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2

Stable Identifier

R-HSA-5686469

Type

Reaction [BlackBoxEvent]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Double-Strand Break Repair (Homo sapiens)
  - Homology Directed Repair (Homo sapiens)
    - HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA) (Homo sapiens)
      - HDR through Homologous Recombination (HRR) (Homo sapiens)
        
        Resolution of D-Loop Structures (Homo sapiens)
        
        Resolution of D-loop Structures through Holliday Junction Intermediates (Homo sapiens)
        
        Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Homo sapiens)

Summation

Based on studies in yeast, D-loop cleavage by MUS81 in complex with EME1 or EME2 always produces crossovers between sister chromatids (Osman et al. 2003). The identity of the DNA polymerase(s) and ligase(s) that complete DNA repair synthesis and ligation after MUS81:EME1 or MUS81:EME2 cleavage of D-loops has not been determined.

Literature References

PubMed ID	Title	Journal	Year
14527420	Generating crossovers by resolution of nicked Holliday junctions: a role for Mus81-Eme1 in meiosis	Mol. Cell	2003

Participants

Input

Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1:CX3 complex [nucleoplasm] (Homo sapiens)

Output

Participant Of

hasEvent

Resolution of D-loop Structures through Holliday Junction Intermediates

Orthologous Events

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Bos taurus)

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Canis familiaris)

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Gallus gallus)

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Sus scrofa)

Resolution of D-loops cleaved by MUS81:EME1 or MUS81:EME2 (Xenopus tropicalis)