KPNA2 translocates NBN to the nucleus

Stable Identifier
R-HSA-5684006
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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KPNA2 translocates NBN to the nucleus
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KPNA2 facilitates the translocation of NBN (NBS1) to the nucleus, thereby making NBN available for the formation of MRN complexes in response to DNA double-strand breaks (DSBs) (Tseng et al. 2005).

Literature References
PubMed ID Title Journal Year
16188882 Importin KPNA2 is required for proper nuclear localization and multiple functions of NBS1

Wu, KJ, Chang, CY, Teng, SC, Tseng, SF

J. Biol. Chem. 2005
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Orthologous Events
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KPNA2 translocates NBN to the nucleus (Drosophila melanogaster)
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KPNA2 translocates NBN to the nucleus (Mus musculus)
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KPNA2 translocates NBN to the nucleus (Sus scrofa)
KPNA2 translocates NBN to the nucleus (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)
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