p-T68-CHEK2 dimerizes

Stable Identifier
R-HSA-5683774
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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ATM-mediated phosphorylation of CHEK2 (CHK2, Cds1) on threonine residue T68 promotes formation of transitional CHEK2 homodimers primarily through intermolecular interactions of FHA domains and phospho-T68 residues of two CHEK2 protomers (Cai et al. 2009).

Literature References
PubMed ID Title Journal Year
19782031 Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase

Cai, Z, Chehab, NH, Pavletich, NP

Mol. Cell 2009
Participants
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Orthologous Events
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Created