p-T68-CHEK2 dimerizes

Stable Identifier
R-HSA-5683774
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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p-T68-CHEK2 dimerizes
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ATM-mediated phosphorylation of CHEK2 (CHK2, Cds1) on threonine residue T68 promotes formation of transitional CHEK2 homodimers primarily through intermolecular interactions of FHA domains and phospho-T68 residues of two CHEK2 protomers (Cai et al. 2009).

Literature References
PubMed ID Title Journal Year
19782031 Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase

Cai, Z, Pavletich, NP, Chehab, NH

Mol. Cell 2009
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Orthologous Events
p-T68-CHEK2 dimerizes (Bos taurus)
p-T68-CHEK2 dimerizes (Caenorhabditis elegans)
p-T68-CHEK2 dimerizes (Danio rerio)
p-T68-CHEK2 dimerizes (Dictyostelium discoideum)
p-T68-CHEK2 dimerizes (Drosophila melanogaster)
p-T68-CHEK2 dimerizes (Gallus gallus)
p-T68-CHEK2 dimerizes (Mus musculus)
p-T68-CHEK2 dimerizes (Plasmodium falciparum)
p-T68-CHEK2 dimerizes (Rattus norvegicus)
p-T68-CHEK2 dimerizes (Saccharomyces cerevisiae)
p-T68-CHEK2 dimerizes (Schizosaccharomyces pombe)
p-T68-CHEK2 dimerizes (Sus scrofa)
Authored
Orlic-Milacic, M  (2015-05-12)
Reviewed
Borowiec, JA  (2015-06-12)
Created
Orlic-Milacic, M  (2015-03-17)
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