Reactome | RNF8 and RNF168 ubiquitinate KDM4A,B

RNF8 and RNF168 ubiquitinate KDM4A,B

Stable Identifier

R-HSA-5683077

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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RNF8 and RNF168 polyubiquitinate KDM4A and KDM4B via ubiquitin lysine K48 cross-linking, leading to dissociation of ubiquitinated KDM4A and KDM4B from H4K20Me2 (Me2-K21-HIST1H4A) and subsequent proteasome-mediated degradation of KDM4A and KDM4B (Mallette et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22373579	RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites Sixma, TK, Cui, G, Mer, G, Richard, S, Young, LC, Mallette, FA, Hendzel, MJ, Mattiroli, F	EMBO J.	2012

Participants

Input

Output

Participates

as an event of

Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)

Catalyst Activity

K48-linked polyubiquitin modification-dependent protein binding activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]

Physical Entity

DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] (Homo sapiens)

Activity

K48-linked polyubiquitin modification-dependent protein binding (GO:0036435)

Orthologous Events

RNF8 and RNF168 ubiquitinate KDM4A,B (Bos taurus)

RNF8 and RNF168 ubiquitinate KDM4A,B (Canis familiaris)

RNF8 and RNF168 ubiquitinate KDM4A,B (Drosophila melanogaster)

RNF8 and RNF168 ubiquitinate KDM4A,B (Gallus gallus)

RNF8 and RNF168 ubiquitinate KDM4A,B (Mus musculus)

RNF8 and RNF168 ubiquitinate KDM4A,B (Rattus norvegicus)

RNF8 and RNF168 ubiquitinate KDM4A,B (Saccharomyces cerevisiae)