RNF8 and RNF168 ubiquitinate KDM4A,B

Stable Identifier
R-HSA-5683077
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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RNF8 and RNF168 polyubiquitinate KDM4A and KDM4B via ubiquitin lysine K48 cross-linking, leading to dissociation of ubiquitinated KDM4A and KDM4B from H4K20Me2 (Me2-K21-HIST1H4A) and subsequent proteasome-mediated degradation of KDM4A and KDM4B (Mallette et al. 2012).

Literature References
PubMed ID Title Journal Year
22373579 RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Mallette, FA, Mattiroli, F, Cui, G, Young, LC, Hendzel, MJ, Mer, G, Sixma, TK, Richard, S

EMBO J. 2012
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
K48-linked polyubiquitin modification-dependent protein binding activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
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Created