PEA15 is a cytoplasmic anchor that binds directly to activated MAPKs prevents their translocation into the nucleus (Formstecher et al, 2001; Whitehurst et al, 2004; Hill et al, 2002; Chou et al, 2003). PEA15 also protects phosphorylated MAPKs in the cytoplasm from inactivating dephosphorylation (Mace et al, 2013). In this way, binding of PEA15 promotes phosphorylation of cytoplasmic MAPK targets at the expense of nuclear ones.
Ginsberg, MH, Uberall, F, Brunet, A, Ramos, JW, Pouysségur, J, Glading, A, Hsieh, JC, Hill, JM, Chou, FL, Werner, MH
Ginsberg, MH, Chneiweiss, H, Ramos, JW, Canton, B, Formstecher, E, Nguyen, XT, Hsieh, JC, Fauquet, M, Calderwood, DA, Camonis, J, Barnier, JV
Cobb, MH, Moore, MS, Robinson, FL, Whitehurst, AW
Robinson, H, Riedl, SJ, Pasquale, EB, Egger, MF, Wallez, Y, Mace, PD, Dobaczewska, MK
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