Reactome | PEA15 binds MAPK monomers and dimers

PEA15 binds MAPK monomers and dimers

Stable Identifier

R-HSA-5675206

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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PEA15 is a cytoplasmic anchor that binds directly to activated MAPKs prevents their translocation into the nucleus (Formstecher et al, 2001; Whitehurst et al, 2004; Hill et al, 2002; Chou et al, 2003). PEA15 also protects phosphorylated MAPKs in the cytoplasm from inactivating dephosphorylation (Mace et al, 2013). In this way, binding of PEA15 promotes phosphorylation of cytoplasmic MAPK targets at the expense of nuclear ones.

Literature References

PubMed ID	Title	Journal	Year
14506247	PEA-15 binding to ERK1/2 MAPKs is required for its modulation of integrin activation Ginsberg, MH, Uberall, F, Brunet, A, Ramos, JW, Pouysségur, J, Glading, A, Hsieh, JC, Hill, JM, Chou, FL, Werner, MH	J. Biol. Chem.	2003
11702783	PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase Ginsberg, MH, Chneiweiss, H, Ramos, JW, Canton, B, Formstecher, E, Nguyen, XT, Hsieh, JC, Fauquet, M, Calderwood, DA, Camonis, J, Barnier, JV	Dev. Cell	2001
14707138	The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions Cobb, MH, Moore, MS, Robinson, FL, Whitehurst, AW	J. Biol. Chem.	2004
23575685	Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK Robinson, H, Riedl, SJ, Pasquale, EB, Egger, MF, Wallez, Y, Mace, PD, Dobaczewska, MK	Nat Commun	2013