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BRAP:KSR1:MARK3 [cytosol]
Stable Identifier
R-HSA-5674011
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
Signaling by RAS mutants (Homo sapiens)
Signaling downstream of RAS mutants (Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
Signaling by moderate kinase activity BRAF mutants (Homo sapiens)
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
BRAP binds KSR1:MARK3 (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
RAF activation (Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers (Homo sapiens)
BRAP:KSR1:MARK3 [cytosol] (Homo sapiens)
Participants
components
BRAP [cytosol]
(Homo sapiens)
KSR1:MARK3 [cytosol]
(Homo sapiens)
Participates
as an output of
BRAP binds KSR1:MARK3 (Homo sapiens)
This entity regulates
Negatively
Inactive BRAF mutants:mutant RAS:GTP bind RAF1
(Homo sapiens)
Moderate kinase activity BRAF mutants:RAS:GTP homo/heterodimerize
(Homo sapiens)
Homo- or heterodimerization of RAF downstream of mutant RAS
(Homo sapiens)
RAS:GTP:'activator' RAF homo/heterodimerizes with other RAF monomers
(Homo sapiens)
Inferred To
BRAP:KSR1:MARK3 [cytosol]
(Bos taurus)
BRAP:KSR1:MARK3 [cytosol]
(Caenorhabditis elegans)
BRAP:KSR1:MARK3 [cytosol]
(Canis familiaris)
BRAP:KSR1:MARK3 [cytosol]
(Dictyostelium discoideum)
BRAP:KSR1:MARK3 [cytosol]
(Drosophila melanogaster)
BRAP:KSR1:MARK3 [cytosol]
(Mus musculus)
BRAP:KSR1:MARK3 [cytosol]
(Plasmodium falciparum)
BRAP:KSR1:MARK3 [cytosol]
(Rattus norvegicus)
BRAP:KSR1:MARK3 [cytosol]
(Sus scrofa)
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