BRAP binds KSR1:MARK3

Stable Identifier
R-HSA-5674019
Type
Reaction
Species
Homo sapiens
Compartment
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BRAP is a negative regulator of MAPK signaling that binds KSR1 as assessed by coimmunoprecipitation. This interaction abrogates KSR1 homodimer and KSR1:RAF heterodimer formation, and disrupts the recruitment of MAP2K kinases to RAF (Methany et al, 2004; Chen et al, 2008; reviewed in Methany et al, 2009). BRAP inhibition of KSR1 is relieved in an unknown manner by autoubiquitination after RAS pathway activation (reviewed in Methany et al, 2009).

Literature References
PubMed ID Title Journal Year
14724641 Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP

White, MA, Kortum, RL, Lewis, RE, Razidlo, GL, Matheny, SA, Chen, C

Nature 2004
18332145 IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds

White, MA, Lewis, RE, Chen, C

J. Biol. Chem. 2008
19091743 Signaling threshold regulation by the Ras effector IMP

White, MA, Matheny, SA

J. Biol. Chem. 2009
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