CIT-3 binds DLG4

Stable Identifier
Homo sapiens
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CIT-3 (CIT-N, citron-N or citron) is a splicing isoform of CIT that lacks the N-terminal kinase domain. CIT-3 is specifically expressed in the brain, where it participates in the formation of postsynaptic densities at glutamatergic synapses by binding to the postsynaptic density protein PSD-95 (DLG4). Binding of CIT-3 to DLG4 is RHO GTPase-dependent. DLG4 may simultaneously bind CIT-3 and NMDA-type glutamate receptors (Zhang et al. 1999, Furuyashiki et al. 1999, Zhang and Benson 2006).

Literature References
PubMed ID Title Journal Year
9870943 Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus

Madaule, P, Mishina, M, Fujita, A, Fujisawa, K, Uchino, S, Narumiya, S, Furuyashiki, T, Bito, H

J. Neurosci. 1999
9870942 Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus

Vazquez, L, Zhang, W, Apperson, M, Kennedy, MB

J. Neurosci. 1999
16202622 Targeting and clustering citron to synapses

Benson, DL, Zhang, W

Mol. Cell. Neurosci. 2006
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