CIT-3 (CIT-N, citron-N or citron) is a splicing isoform of CIT that lacks the N-terminal kinase domain. CIT-3 is specifically expressed in the brain, where it participates in the formation of postsynaptic densities at glutamatergic synapses by binding to the postsynaptic density protein PSD-95 (DLG4). Binding of CIT-3 to DLG4 is RHO GTPase-dependent. DLG4 may simultaneously bind CIT-3 and NMDA-type glutamate receptors (Zhang et al. 1999, Furuyashiki et al. 1999, Zhang and Benson 2006).
Zhang, W, Vazquez, L, Apperson, M, Kennedy, MB
Furuyashiki, T, Fujisawa, K, Fujita, A, Madaule, P, Uchino, S, Mishina, M, Bito, H, Narumiya, S
Zhang, W, Benson, DL
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