Reactome | CIT-3 binds DLG4

CIT-3 binds DLG4

Stable Identifier

R-HSA-5671993

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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CIT-3 (CIT-N, citron-N or citron) is a splicing isoform of CIT that lacks the N-terminal kinase domain. CIT-3 is specifically expressed in the brain, where it participates in the formation of postsynaptic densities at glutamatergic synapses by binding to the postsynaptic density protein PSD-95 (DLG4). Binding of CIT-3 to DLG4 is RHO GTPase-dependent. DLG4 may simultaneously bind CIT-3 and NMDA-type glutamate receptors (Zhang et al. 1999, Furuyashiki et al. 1999, Zhang and Benson 2006).

Literature References

PubMed ID	Title	Journal	Year
9870943	Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus Furuyashiki, T, Fujisawa, K, Fujita, A, Madaule, P, Uchino, S, Mishina, M, Bito, H, Narumiya, S	J. Neurosci.	1999
9870942	Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus Zhang, W, Vazquez, L, Apperson, M, Kennedy, MB	J. Neurosci.	1999
16202622	Targeting and clustering citron to synapses Zhang, W, Benson, DL	Mol. Cell. Neurosci.	2006