CIT-3 binds DLG4

Stable Identifier
R-HSA-5671993
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
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CIT-3 binds DLG4
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CIT-3 (CIT-N, citron-N or citron) is a splicing isoform of CIT that lacks the N-terminal kinase domain. CIT-3 is specifically expressed in the brain, where it participates in the formation of postsynaptic densities at glutamatergic synapses by binding to the postsynaptic density protein PSD-95 (DLG4). Binding of CIT-3 to DLG4 is RHO GTPase-dependent. DLG4 may simultaneously bind CIT-3 and NMDA-type glutamate receptors (Zhang et al. 1999, Furuyashiki et al. 1999, Zhang and Benson 2006).

Literature References
PubMed ID Title Journal Year
9870942 Citron binds to PSD-95 at glutamatergic synapses on inhibitory neurons in the hippocampus

Zhang, W, Vazquez, L, Apperson, M, Kennedy, MB

J. Neurosci. 1999
9870943 Citron, a Rho-target, interacts with PSD-95/SAP-90 at glutamatergic synapses in the thalamus

Furuyashiki, T, Fujisawa, K, Fujita, A, Madaule, P, Uchino, S, Mishina, M, Bito, H, Narumiya, S

J. Neurosci. 1999
16202622 Targeting and clustering citron to synapses

Zhang, W, Benson, DL

Mol. Cell. Neurosci. 2006
Participants
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Orthologous Events
CIT-3 binds DLG4 (Bos taurus)
CIT-3 binds DLG4 (Canis familiaris)
CIT-3 binds DLG4 (Danio rerio)
CIT-3 binds DLG4 (Drosophila melanogaster)
CIT-3 binds DLG4 (Mus musculus)
CIT-3 binds DLG4 (Rattus norvegicus)
CIT-3 binds DLG4 (Sus scrofa)
CIT-3 binds DLG4 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-10-24)
Rivero Crespo, F  (2014-12-26)
Created
Orlic-Milacic, M  (2015-02-04)