Reactome | RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

Stable Identifier

R-HSA-5666104

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

ReviewStatus

5/5

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RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

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RHOD:GTP:DIAPH2-3 complex recruits SRC to endosomes. SRC recruitment is necessary for RHOD:GTP:DIAPH2-3-mediated regulation of endosome-associated actin cytoskeleton and endosome motility (Gasman et al. 2003). SRC directly binds to DIAPH2 (Tominaga et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10678165	Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling McCormick, F, Chardin, P, Courtneidge, SA, Alberts, AS, Tominaga, T, Sahai, E	Mol. Cell	2000
12577064	RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase Kalaidzidis, Y, Gasman, S, Zerial, M	Nat. Cell Biol.	2003