RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

Stable Identifier
R-HSA-5666104
Type
Reaction
Species
Homo sapiens
Compartment
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RHOD:GTP:DIAPH2-3 complex recruits SRC to endosomes. SRC recruitment is necessary for RHOD:GTP:DIAPH2-3-mediated regulation of endosome-associated actin cytoskeleton and endosome motility (Gasman et al. 2003). SRC directly binds to DIAPH2 (Tominaga et al. 2000).

Literature References
PubMed ID Title Journal Year
10678165 Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling

McCormick, F, Chardin, P, Courtneidge, SA, Alberts, AS, Tominaga, T, Sahai, E

Mol. Cell 2000
12577064 RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase

Kalaidzidis, Y, Gasman, S, Zerial, M

Nat. Cell Biol. 2003
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