Reactome | RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

Stable Identifier

R-HSA-5666104

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, endosome membrane

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RHOD:GTP:DIAPH2-3 recruits SRC-1 to endosomes

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RHOD:GTP:DIAPH2-3 complex recruits SRC to endosomes. SRC recruitment is necessary for RHOD:GTP:DIAPH2-3-mediated regulation of endosome-associated actin cytoskeleton and endosome motility (Gasman et al. 2003). SRC directly binds to DIAPH2 (Tominaga et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
12577064	RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase Gasman, S, Kalaidzidis, Y, Zerial, M	Nat. Cell Biol.	2003
10678165	Diaphanous-related formins bridge Rho GTPase and Src tyrosine kinase signaling Tominaga, T, Sahai, E, Chardin, P, McCormick, F, Courtneidge, SA, Alberts, AS	Mol. Cell	2000