NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors

Stable Identifier
R-HSA-5663271
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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NR1D1 (REV-ERBA) binds the promoter of the CLOCK gene and recruits corepressors to repress transcription. Recruitment of repressors appears to depend on the binding of heme by NR1D1.

Literature References
PubMed ID Title Journal Year
21479263 Direct regulation of CLOCK expression by REV-ERB

Crumbley, C, Burris, TP

PLoS One 2011
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