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NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors
Stable Identifier
R-HSA-5663271
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)
Circadian Clock (Homo sapiens)
NR1D1 (REV-ERBA) binds heme, the CLOCK gene, and recruits corepressors (Homo sapiens)
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NR1D1 (REV-ERBA) binds the promoter of the CLOCK gene and recruits corepressors to repress transcription. Recruitment of repressors appears to depend on the binding of heme by NR1D1.
Literature References
PubMed ID
Title
Journal
Year
21479263
Direct regulation of CLOCK expression by REV-ERB
Crumbley, C
,
Burris, TP
PLoS One
2011
Participants
Input
CLOCK gene [nucleoplasm]
(Homo sapiens)
ferriheme b [nucleoplasm]
HDAC3 [nucleoplasm]
(Homo sapiens)
NCOR1 [nucleoplasm]
(Homo sapiens)
NR1D1 [nucleoplasm]
(Homo sapiens)
Output
NR1D1:heme:Corepressors:CLOCK gene [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Circadian Clock (Homo sapiens)
Heme signaling (Homo sapiens)
Authored
May, B (2015-01-16)
Reviewed
Somers, J (2021-01-23)
Delaunay, F (2012-01-28)
Created
May, B (2015-01-17)
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