ASC (adaptor protein apoptosis-associated speck-like protein containing a CARD) is a pro-apoptotic protein containing a pyrin domain (PD) and a caspase-recruitment domain (CARD). ASC with its PD domain physically interacts with caspase-8. Formation of the MALT1–caspase-8 complex is a prerequisite for the association of caspase-8 with ASC. ASC is necessary for the recruitment of pro-IL1B into the proximity of activated caspase-8 (Gringhuis et al. 2012).
Geijtenbeek, TB, Gringhuis, SI, Boekhout, T, Theelen, B, Wevers, BA, van der Vlist, M, Kaptein, TM
Zhu, L, Li, M, Sagara, J, Taniguchi, S, Masumoto, J, Dowds, TA, Núñez, G, Schaner, P, Chen, FF, Katsuyama, T, Gumucio, DL, Ogura, Y, Inohara, N
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