Reactome | ASC binds Caspase-8 complex

ASC binds Caspase-8 complex

Stable Identifier

R-HSA-5660662

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ASC (adaptor protein apoptosis-associated speck-like protein containing a CARD) is a pro-apoptotic protein containing a pyrin domain (PD) and a caspase-recruitment domain (CARD). ASC with its PD domain physically interacts with caspase-8. Formation of the MALT1–caspase-8 complex is a prerequisite for the association of caspase-8 with ASC. ASC is necessary for the recruitment of pro-IL1B into the proximity of activated caspase-8 (Gringhuis et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
22267217	Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1? via a noncanonical caspase-8 inflammasome Gringhuis, SI, Kaptein, TM, Wevers, BA, Theelen, B, van der Vlist, M, Boekhout, T, Geijtenbeek, TB	Nat. Immunol.	2012
12646168	ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis Masumoto, J, Dowds, TA, Schaner, P, Chen, FF, Ogura, Y, Li, M, Zhu, L, Katsuyama, T, Sagara, J, Taniguchi, S, Gumucio, DL, Núñez, G, Inohara, N	Biochem. Biophys. Res. Commun.	2003