Activated FGFR4 mutants bind PLCG1

Stable Identifier
Reaction [binding]
Homo sapiens
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Although it has not been rigourously established, there is some evidence that PLC-gamma signaling may be activated after autophosphorylation of some FGFR mutants, analagous to the wild type receptor (see for instance, Hart, 2000; Chen, 2005; Cha, 2008; di Martino, 2009; Gartside, 2009; Cross, 2000; Hatch, 2006). The extent to which each of the mutants activates this pathway and to which proliferation and tumorigenesis relies on PLC-gamma dependent signaling, remains to be more firmly established.
Literature References
PubMed ID Title Journal Year
18337450 Involvement of fibroblast growth factor receptor 2 isoform switching in mammary oncogenesis

Der, CJ, Cha, JY, Lambert, QT, Reuther, GW

Mol Cancer Res 2008
16091734 FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies

Gilliland, DG, Cohen, S, Huntly, BJ, Griffin, J, Duclos, N, Fabbro, D, Okabe, R, Moore, S, Mitsiades, CS, Lee, BH, Chen, J, Kutok, J, Adelsperger, J, Anderson, KC, Coburn, A, Williams, I

Oncogene 2005
10918587 Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4

Tynan, JA, Donoghue, DJ, Hart, KC, Kanemitsu, MY, Robertson, SC, Meyer, AN

Oncogene 2000
19749790 Mutant fibroblast growth factor receptor 3 induces intracellular signaling and cellular transformation in a cell type- and mutation-specific manner

Knowles, MA, di Martino, E, L'Hote, CG, Tomlinson, DC, Kennedy, W

Oncogene 2009
10652257 Tyrosine 766 in the fibroblast growth factor receptor-1 is required for FGF-stimulation of phospholipase C, phospholipase D, phospholipase A(2), phosphoinositide 3-kinase and cytoskeletal reorganisation in porcine aortic endothelial cells

Landgren, E, Hodgkin, MN, Roberts, S, Cross, MJ, Claesson-Welsh, L, Wakelam, MJ

J Cell Sci 2000
19147536 Loss-of-function fibroblast growth factor receptor-2 mutations in melanoma

Pollock, PM, Eliseenkova, AV, Wellens, CL, Curtis, AV, Gartside, MG, Bastian, BC, Byron, SA, Bengston, A, Riedesel, E, Mann, GJ, Harper, UL, Yudt, LM, Hyder, P, Chen, H, Mohammadi, M, Meltzer, PS, Ibrahimi, OA, Ma, J, Trent, JM, Curtin, JA

Mol Cancer Res 2009
16844695 Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F

Hatch, NE, Hudson, M, Cunningham, ML, Seto, ML, Bothwell, M

J Biol Chem 2006
Normal reaction
Functional status

Gain of function of Activated FGFR4 mutants [plasma membrane]

Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
bone development disease DOID:0080006
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