Reactome | SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH

SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH

Stable Identifier

R-HSA-5654985

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH

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SPRTN (Spartan, C1orf124, DVC1) contains a SHP box that binds the hexameric AAA-ATPase VCP (p97). SPRTN recruits VCP, in complex with VCP adaptors NPLOC4 and UFD1L, to monoubiquitinated PCNA (MonoUb:K164-PCNA) associated with POLH at DNA damage sites (Ghosal et al. 2012, Davis et al. 2012, Mosbech et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23042607	DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage Davis, EJ, Lachaud, C, Näthke, I, Appleton, P, Rouse, J, Macartney, TJ	Nat. Struct. Mol. Biol.	2012
23042605	DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks Hartmann-Petersen, R, Lukas, J, Beli, P, Lukas, C, Choudhary, C, Gibbs-Seymour, I, Bekker-Jensen, S, Mailand, N, Pocock, R, Mosbech, A, Povlsen, L, Smedegaard, S, Nielsen, SV, Kagias, K, Sedgwick, G, Thorslund, T	Nat. Struct. Mol. Biol.	2012
22902628	Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis Leung, JW, Fong, KW, Chen, J, Nair, BC, Ghosal, G	J. Biol. Chem.	2012