SPRTN recruits VCP to monoUb:K164-PCNA associated with POLH

Stable Identifier
Reaction [binding]
Homo sapiens
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SPRTN (Spartan, C1orf124, DVC1) contains a SHP box that binds the hexameric AAA-ATPase VCP (p97). SPRTN recruits VCP, in complex with VCP adaptors NPLOC4 and UFD1L, to monoubiquitinated PCNA (MonoUb:K164-PCNA) associated with POLH at DNA damage sites (Ghosal et al. 2012, Davis et al. 2012, Mosbech et al. 2012).

Literature References
PubMed ID Title Journal Year
23042607 DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Davis, EJ, Lachaud, C, Näthke, I, Appleton, P, Rouse, J, Macartney, TJ

Nat. Struct. Mol. Biol. 2012
23042605 DVC1 (C1orf124) is a DNA damage-targeting p97 adaptor that promotes ubiquitin-dependent responses to replication blocks

Hartmann-Petersen, R, Lukas, J, Beli, P, Lukas, C, Choudhary, C, Gibbs-Seymour, I, Bekker-Jensen, S, Mailand, N, Pocock, R, Mosbech, A, Povlsen, L, Smedegaard, S, Nielsen, SV, Kagias, K, Sedgwick, G, Thorslund, T

Nat. Struct. Mol. Biol. 2012
22902628 Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis

Leung, JW, Fong, KW, Chen, J, Nair, BC, Ghosal, G

J. Biol. Chem. 2012
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