Reactome | Activated FGFR3 phosphorylates SHC1

Activated FGFR3 phosphorylates SHC1

Stable Identifier

R-HSA-5654634

Type

Reaction

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR3 (Homo sapiens)
      - Downstream signaling of activated FGFR3 (Homo sapiens)
        
        SHC-mediated cascade:FGFR3 (Homo sapiens)
        
        Activated FGFR3 phosphorylates SHC1 (Homo sapiens)

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The p46 and p53 isoforms of SHC1 have been shown to be phosphorylated upon FGF stimulation. Three consensus RTK phosphoryation sites are present in SHC1, although phosphorylation of these specific tyrosine residues has not been explicitly demonstrated in response to FGF stimulation. In contrast, the p66 isoform of SHC1 does not appear to undergo FGF-dependent phosphorylation.

Literature References

PubMed ID	Title	Journal	Year
7559490	Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells Kanda, S, Klint, P, Claesson-Welsh, L	J Biol Chem	1995
8264585	Fibroblast growth factor receptors have different signaling and mitogenic potentials Wang, JK, Goldfarb, M, Gao, G	Mol Cell Biol	1994
9045692	Signal transduction pathway of human fibroblast growth factor receptor 3. Identification of a novel 66-kDa phosphoprotein. Podolsky, DK, Goke, M, Tsunekawa, S, Kanai, M	J Biol Chem	1997
18840094	Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2) Suhling, K, Levitt, JA, Ladbury, JE, Suen, KM, Ahmed, Z, Schüller, AC	Biochem J	2008