Activated FGFR3 phosphorylates PPTN11

Stable Identifier
Reaction [transition]
Homo sapiens
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Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is required for activation of the phosphatase activity of PPTN11 and for downstream signaling. Tyrosine phosphorylated PPTN11 plays a major role in the activation of RAS-MAP kinase pathway, although the precise role is not yet clear.

Literature References
PubMed ID Title Journal Year
18373495 Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Tregidgo, C, Suhling, K, Ladbury, JE, Ahmed, Z, Schüller, AC

Biochem J 2008
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Ischenko, I, Movilla, N, Agazie, YM, Hayman, MJ

Oncogene 2003
9299490 SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells

Lim, YP, Low, BC, Ong, SH, Guy, GR

Biochem Biophys Res Commun 1997
Catalyst Activity

protein tyrosine kinase activity of Activated FGFR3:p-FRS:PTPN11 [plasma membrane]

Orthologous Events
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