Reactome | Activated FGFR2:pFRS binds GRB2:SOS1

Activated FGFR2:pFRS binds GRB2:SOS1

Stable Identifier

R-HSA-5654615

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR2 (Homo sapiens)
      - Downstream signaling of activated FGFR2 (Homo sapiens)
        
        FRS-mediated FGFR2 signaling (Homo sapiens)
        
        Activated FGFR2:pFRS binds GRB2:SOS1 (Homo sapiens)

General

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Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:PPTN11.

Literature References

PubMed ID	Title	Journal	Year
9182757	A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D	Cell	1997
7559490	Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells Kanda, S, Klint, P, Claesson-Welsh, L	J Biol Chem	1995
11353842	Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR	Proc Natl Acad Sci U S A	2001
11447289	Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways Schlessinger, J, Kouhara, H, Lax, I, Gotoh, N, Hadari, YR	Proc Natl Acad Sci U S A	2001
8780727	Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2 Goh, KC, Lim, YP, Klint, P, Tan, YH, Low, BC, Ong, SH, Cao, X, Claesson-Welsh, L, Guy, GR	Biochem Biophys Res Commun	1996