Activated FGFR1:p-FRS phosphorylates PPTN11

Stable Identifier
R-HSA-5654587
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Tyrosine phosphorylation of PPTN11/SHP2 by FGFR kinase is required for activation of the phosphatase activity of PPTN11 and for downstream signaling. Tyrosine phosphorylated PPTN11 plays a major role in the activation of RAS-MAP kinase pathway, although the precise role is not yet clear.

Literature References
PubMed ID Title Journal Year
14534538 The phosphotyrosine phosphatase SHP2 is a critical mediator of transformation induced by the oncogenic fibroblast growth factor receptor 3

Agazie, YM, Movilla, N, Ischenko, I, Hayman, MJ

Oncogene 2003
18373495 Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling

Ahmed, Z, Schüller, AC, Suhling, K, Tregidgo, C, Ladbury, JE

Biochem J 2008
9299490 SHP2 associates directly with tyrosine phosphorylated p90 (SNT) protein in FGF-stimulated cells

Ong, SH, Lim, YP, Low, BC, Guy, GR

Biochem Biophys Res Commun 1997
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Activated FGFR1:p-FRS:PTPN11 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed