Activated FGFR1:p-FRS binds GRB2:SOS1

Stable Identifier
Reaction [binding]
Homo sapiens
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Tyrosine phosphorylated FRS2 recruits GRB2:SOS1 complex by means of the SH3 domain of GRB2, leading to RAS-MAP kinase activation. The FRS2:GRB2-mediated pathway plays a minor role in the activation of RAS-MAP kinase pathway compared to that mediated by FRS2:PPTN11.
Literature References
PubMed ID Title Journal Year
9182757 A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway

Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D

Cell 1997
7559490 Shc and a novel 89-kDa component couple to the Grb2-Sos complex in fibroblast growth factor-2-stimulated cells

Kanda, S, Klint, P, Claesson-Welsh, L

J Biol Chem 1995
11353842 Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

Ong, SH, Schlessinger, J, Lax, I, Gotoh, N, Hadari, YR, Guy, GR

Proc Natl Acad Sci U S A 2001
11447289 Critical role for the docking-protein FRS2 alpha in FGF receptor-mediated signal transduction pathways

Schlessinger, J, Kouhara, H, Lax, I, Gotoh, N, Hadari, YR

Proc Natl Acad Sci U S A 2001
8780727 Suc1-associated neurotrophic factor target (SNT) protein is a major FGF-stimulated tyrosine phosphorylated 90-kDa protein which binds to the SH2 domain of GRB2

Goh, KC, Lim, YP, Klint, P, Tan, YH, Low, BC, Ong, SH, Cao, X, Claesson-Welsh, L, Guy, GR

Biochem Biophys Res Commun 1996
Orthologous Events
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