Reactome | Activated FGFR1 phosphorylates FRS3

Activated FGFR1 phosphorylates FRS3

Stable Identifier

R-HSA-5654578

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol, extracellular region

ReviewStatus

5/5

Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by FGFR (Homo sapiens)
    - Signaling by FGFR1 (Homo sapiens)
      - Downstream signaling of activated FGFR1 (Homo sapiens)
        
        FRS-mediated FGFR1 signaling (Homo sapiens)
        
        Activated FGFR1 phosphorylates FRS3 (Homo sapiens)

General

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FRS3 (also known as FRS2 beta) is activated through tyrosine phosphorylation catalyzed by the protein kinase domain of the activated FGFR. By sequence comparison, FRS3 has the 2 PPTN11/SHP2-binding sites and has three of the four GRB2-binding sites.

Literature References

PubMed ID	Title	Journal	Year
12419216	The docking protein FRS2alpha controls a MAP kinase-mediated negative feedback mechanism for signaling by FGF receptors Frost, A, Wong, A, Hawes, J, Lee, A, Lamothe, B, Schlessinger, J, Lax, I	Mol Cell	2002
9182757	A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway Schlessinger, J, Kouhara, H, Lax, I, Schilling, J, Spivak-Kroizman, T, Hadari, YR, Bar-Sagi, D	Cell	1997