RAD18:UBE2B or RBX1:CUL4:DDB1:DTL ubiquitin ligase complex binds PCNA:POLD,POLE:RPA:RFC associated with damaged dsDNA

Stable Identifier
R-HSA-5652005
Type
Reaction [binding]
Species
Homo sapiens
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The complex of RAD18, an E3 ubiquitin ligase, and UBE2B (RAD6), an E2 ubiquitin-conjugating enzyme, binds the replication complex consisting of PCNA, DNA polymerase complex delta (POLD) or DNA polymerase complex epsilon (POLE), RPA and RFC on damaged dsDNA. RAD18 simultaneously interacts with PCNA, RPA and DNA (Hoege et al. 2002, Notenboom et al. 2007, Davies et al. 2008). The ubiquitin ligase complex RBX1:CUL4:DDB1:DTL can also bind PCNA (Terai et al. 2010).

Literature References
PubMed ID Title Journal Year
12226657 RAD6-dependent DNA repair is linked to modification of PCNA by ubiquitin and SUMO

Hoege, C, Pfander, B, Moldovan, GL, Pyrowolakis, G, Jentsch, S

Nature 2002
18342608 Activation of ubiquitin-dependent DNA damage bypass is mediated by replication protein a

Davies, AA, Huttner, D, Daigaku, Y, Chen, S, Ulrich, HD

Mol. Cell 2008
17720710 Functional characterization of Rad18 domains for Rad6, ubiquitin, DNA binding and PCNA modification

Notenboom, V, Hibbert, RG, van Rossum-Fikkert, SE, Olsen, JV, Mann, M, Sixma, TK

Nucleic Acids Res. 2007
20129063 CRL4(Cdt2) E3 ubiquitin ligase monoubiquitinates PCNA to promote translesion DNA synthesis

Terai, K, Abbas, T, Jazaeri, AA, Dutta, A

Mol. Cell 2010
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