NEIL2 cleaves 5-OHU from damaged DNA

Stable Identifier
R-HSA-5649681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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NEIL2 acts as a DNA glycosylase to cleave 5'-hydroxyuracil from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).

Literature References
PubMed ID Title Journal Year
12097317 Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Hazra, TK, Kow, YW, Hatahet, Z, Imhoff, B, Boldogh, I, Mokkapati, SK, Mitra, S, Izumi, T

J. Biol. Chem. 2002
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
DNA N-glycosylase activity of NEIL2:5-OHU-dsDNA [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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