NEIL2 cleaves 5-OHU from damaged DNA

Stable Identifier
R-HSA-5649681
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NEIL2 cleaves 5-OHU from damaged DNA
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NEIL2 acts as a DNA glycosylase to cleave 5'-hydroxyuracil from damaged DNA, producing an AP (apurinic/apyrimidinic) site (Hazra et al. 2002).
Literature References
PubMed ID Title Journal Year
12097317 Identification and characterization of a novel human DNA glycosylase for repair of cytosine-derived lesions

Mokkapati, SK, Imhoff, B, Kow, YW, Mitra, S, Izumi, T, Hazra, TK, Hatahet, Z, Boldogh, I

J. Biol. Chem. 2002
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Catalyst Activity

DNA N-glycosylase activity of NEIL2:5-OHU-dsDNA [nucleoplasm]

Physical Entity
NEIL2:5-OHU-dsDNA [nucleoplasm] (Homo sapiens)
Activity
DNA N-glycosylase activity (GO:0019104)
Orthologous Events
NEIL2 cleaves 5-OHU from damaged DNA (Bos taurus)
NEIL2 cleaves 5-OHU from damaged DNA (Canis familiaris)
NEIL2 cleaves 5-OHU from damaged DNA (Gallus gallus)
NEIL2 cleaves 5-OHU from damaged DNA (Mus musculus)
NEIL2 cleaves 5-OHU from damaged DNA (Rattus norvegicus)
NEIL2 cleaves 5-OHU from damaged DNA (Sus scrofa)
NEIL2 cleaves 5-OHU from damaged DNA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2014-12-04)
Reviewed
Borowiec, JA  (2014-12-22)
Created
Orlic-Milacic, M  (2014-11-21)
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