EGFRvIII cancer mutant was not directly tested for its ability to phosphorylate SHC1, but is assumed to interact with SHC1 in the same way as the wild-type EGFR protein (Soler et al. 1994, VanderKuur et al. 1995).
protein tyrosine kinase activity of p-5Y-EGFRvIII:SHC1 [plasma membrane]
Gain of function of p-5Y-EGFRvIII:SHC1 [plasma membrane]