Phosphorylation of SHC1 by p-5Y-EGFRvIII

Stable Identifier
R-HSA-5637796
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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EGFRvIII cancer mutant was not directly tested for its ability to phosphorylate SHC1, but is assumed to interact with SHC1 in the same way as the wild-type EGFR protein (Soler et al. 1994, VanderKuur et al. 1995).

Literature References
PubMed ID Title Journal Year
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G

Oncogene 1994
7535773 Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

VanderKuur, J, Allevato, G, Billestrup, N, Norstedt, G, Carter-Su, C

J Biol Chem 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of p-5Y-EGFRvIII:SHC1 [plasma membrane]
Physical Entity
Activity
Normal reaction
Disease
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Authored
Reviewed
Created
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