SHC1 phosphorylation by phosphorylated EGFR

Stable Identifier
R-HSA-177933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Once bound to EGFR, SHC1 is phosphorylated on two tyrosines (Y349, Y350).

Literature References
PubMed ID Title Journal Year
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Soler, C, Alvarez, CV, Beguinot, L, Carpenter, G

Oncogene 1994
7535773 Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

VanderKuur, J, Allevato, G, Billestrup, N, Norstedt, G, Carter-Su, C

J Biol Chem 1995
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created