SHC1 phosphorylation by phosphorylated EGFR

Stable Identifier
R-HSA-177933
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
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SHC1 phosphorylation by phosphorylated EGFR
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Once bound to EGFR, SHC1 is phosphorylated on two tyrosines (Y349, Y350).
Literature References
PubMed ID Title Journal Year
7535773 Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

Carter-Su, C, Allevato, G, Norstedt, G, Billestrup, N, VanderKuur, J

J Biol Chem 1995
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Alvarez, CV, Soler, C, Beguinot, L, Carpenter, G

Oncogene 1994
Participants
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Output
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as an event of
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]

Physical Entity
EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane] (Homo sapiens)
Activity
transmembrane receptor protein tyrosine kinase activity (GO:0004714)
Orthologous Events
SHC1 phosphorylation by phosphorylated EGFR (Bos taurus)
SHC1 phosphorylation by phosphorylated EGFR (Canis familiaris)
SHC1 phosphorylation by phosphorylated EGFR (Drosophila melanogaster)
SHC1 phosphorylation by phosphorylated EGFR (Gallus gallus)
SHC1 phosphorylation by phosphorylated EGFR (Mus musculus)
SHC1 phosphorylation by phosphorylated EGFR (Rattus norvegicus)
SHC1 phosphorylation by phosphorylated EGFR (Sus scrofa)
SHC1 phosphorylation by phosphorylated EGFR (Xenopus tropicalis)
Authored
Castagnoli, L  (2006-10-10)
Reviewed
Heldin, CH  (2008-02-12)
Created
Jassal, B  (2006-04-11)
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