SHC1 phosphorylation by phosphorylated EGFR

Stable Identifier
R-HSA-177933
Type
Reaction
Species
Homo sapiens
Compartment
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Once bound to EGFR, SHC1 is phosphorylated on two tyrosines (Y349, Y350).

Literature References
PubMed ID Title Journal Year
7535773 Growth hormone-promoted tyrosyl phosphorylation of SHC proteins and SHC association with Grb2

Carter-Su, C, Allevato, G, Norstedt, G, Billestrup, N, VanderKuur, J

J Biol Chem 1995
8036006 Potent SHC tyrosine phosphorylation by epidermal growth factor at low receptor density or in the absence of receptor autophosphorylation sites

Alvarez, CV, Soler, C, Beguinot, L, Carpenter, G

Oncogene 1994
Participants
Participates
Catalyst Activity

transmembrane receptor protein tyrosine kinase activity of EGF-like ligands:p-6Y EGFR:SHC1 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
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