The transcriptional activity of full-length activated Ci/GLI proteins is restricted by their rapid ubiquitin-mediated degradation after initiation of Hh signaling (Ohlmeyer et al, 1998; Humke et al, 2010; Tukachinsky et al, 2010; Wen et al, 2010). Ubiquitination of Ci, GLI2 and GLI3 is mediated by the E3 ligase complex SPOP:CUL3:RBX1, which ubiquitinates the transcription factors in a Hh-dependent manner (Zhang et al, 2006; Kent et al, 2006; Zhang et al, 2009; Chen et al, 2009).
Yue, T, Li, S, Zhang, Q, Wang, B, Shi, Q, Jiang, J, Chen, Y
Hooper, JE, Bush, EW, Kent, D
Li, YJ, Zhang, X, Hui, CC, Chuang, PT, Gacayan, R, Law, KK, Wilson, CW, Lu, CS, Chen, MH
Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ
Ou, CY, Wang, B, Jiang, J, Chien, CT, Zhang, L, Zhang, Q
Milenkovic, L, Rohatgi, R, Scott, MP, Humke, EW, Dorn, KV
Salic, A, Lopez, LV, Tukachinsky, H
Ohlmeyer, JT, Kalderon, D
ubiquitin protein ligase activity of 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm]
© 2022 Reactome
