The transcriptional activity of full-length activated Ci/GLI proteins is restricted by their rapid ubiquitin-mediated degradation after initiation of Hh signaling (Ohlmeyer et al, 1998; Humke et al, 2010; Tukachinsky et al, 2010; Wen et al, 2010). Ubiquitination of Ci, GLI2 and GLI3 is mediated by the E3 ligase complex SPOP:CUL3:RBX1, which ubiquitinates the transcription factors in a Hh-dependent manner (Zhang et al, 2006; Kent et al, 2006; Zhang et al, 2009; Chen et al, 2009).
Kent, D, Bush, EW, Hooper, JE
Zhang, Q, Shi, Q, Chen, Y, Yue, T, Li, S, Wang, B, Jiang, J
Chen, MH, Wilson, CW, Li, YJ, Law, KK, Lu, CS, Gacayan, R, Zhang, X, Hui, CC, Chuang, PT
Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ
Zhang, Q, Zhang, L, Wang, B, Ou, CY, Chien, CT, Jiang, J
Humke, EW, Dorn, KV, Milenkovic, L, Scott, MP, Rohatgi, R
Tukachinsky, H, Lopez, LV, Salic, A
Ohlmeyer, JT, Kalderon, D
ubiquitin protein ligase activity of 2p-GLI:SPOP:CUL3:RBX1 [nucleoplasm]
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