GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters

Stable Identifier
R-HSA-5635850
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Genome-wide ChIP studies have identified Hh pathway members HHIP, PTCH2 and BOC as direct targets of GLI1 downstream of pathway activation (Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010).

Literature References
PubMed ID Title Journal Year
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Vokes, SA, Ji, H, Wong, WH, McMahon, AP

Genes Dev. 2008
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Vokes, SA, Ji, H, McCuine, S, Tenzen, T, Giles, S, Zhong, S, Longabaugh, WJ, Davidson, EH, Wong, WH, McMahon, AP

Development 2007
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Lee, EY, Ji, H, Ouyang, Z, Zhou, B, Ma, W, Vokes, SA, McMahon, AP, Wong, WH, Scott, MP

Proc. Natl. Acad. Sci. U.S.A. 2010
Participants
Participant Of
Authored
Reviewed
Created