GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters

Stable Identifier
R-HSA-5635850
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
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GLI1 binds HHIP gene, PTCH2 gene and BOC gene promoters
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Genome-wide ChIP studies have identified Hh pathway members HHIP, PTCH2 and BOC as direct targets of GLI1 downstream of pathway activation (Vokes et al, 2007; Vokes et al, 2008; Lee et al, 2010).

Literature References
PubMed ID Title Journal Year
17442700 Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning

Davidson, EH, Giles, S, Wong, WH, Longabaugh, WJ, McCuine, S, McMahon, AP, Ji, H, Tenzen, T, Vokes, SA, Zhong, S

Development 2007
18832070 A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

Wong, WH, McMahon, AP, Ji, H, Vokes, SA

Genes Dev. 2008
20460306 Hedgehog pathway-regulated gene networks in cerebellum development and tumorigenesis

Wong, WH, McMahon, AP, Ji, H, Scott, MP, Lee, EY, Vokes, SA, Ma, W, Ouyang, Z, Zhou, B

Proc. Natl. Acad. Sci. U.S.A. 2010
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Authored
Rothfels, K  (2014-10-31)
Reviewed
Liu, Y C  (2014-11-09)
Created
Rothfels, K  (2014-11-07)
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