Activation of SMO downstream of Hh ligand binding results in the dissociation of the SUFU:GLI complex and the translocation of the full-length GLI proteins to the nucleus where it is converted to a short-lived transcriptionally active form (Pan et al, 2006; Kim et al, 2009; Wen et al, 2010; Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Briscoe and Therond, 2013).
Kim, J, Kato, M, Beachy, PA
Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ
Pan, Y, Bai, CB, Wang, B, Joyner, AL
Thérond, PP, Briscoe, J
Milenkovic, L, Rohatgi, R, Scott, MP, Humke, EW, Dorn, KV
Salic, A, Lopez, LV, Tukachinsky, H
© 2022 Reactome
