Reactome | GLI translocates to the nucleus

GLI translocates to the nucleus

Stable Identifier

R-HSA-5635843

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

ciliary tip, nucleoplasm

ReviewStatus

5/5

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Activation of SMO downstream of Hh ligand binding results in the dissociation of the SUFU:GLI complex and the translocation of the full-length GLI proteins to the nucleus where it is converted to a short-lived transcriptionally active form (Pan et al, 2006; Kim et al, 2009; Wen et al, 2010; Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Briscoe and Therond, 2013).

Literature References

PubMed ID	Title	Journal	Year
19996169	Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus Kim, J, Kato, M, Beachy, PA	Proc. Natl. Acad. Sci. U.S.A.	2009
20154143	Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation Scales, SJ, Hongo, JA, Wen, X, Evangelista, M, Lai, CK, de Sauvage, FJ	Mol. Cell. Biol.	2010
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Y, Bai, CB, Wang, B, Joyner, AL	Mol. Cell. Biol.	2006
23719536	The mechanisms of Hedgehog signalling and its roles in development and disease Thérond, PP, Briscoe, J	Nat. Rev. Mol. Cell Biol.	2013
20360384	The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins Milenkovic, L, Rohatgi, R, Scott, MP, Humke, EW, Dorn, KV	Genes Dev.	2010
20956384	A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes Salic, A, Lopez, LV, Tukachinsky, H	J. Cell Biol.	2010