GLI translocates to the nucleus

Stable Identifier
R-HSA-5635843
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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Activation of SMO downstream of Hh ligand binding results in the dissociation of the SUFU:GLI complex and the translocation of the full-length GLI proteins to the nucleus where it is converted to a short-lived transcriptionally active form (Pan et al, 2006; Kim et al, 2009; Wen et al, 2010; Humke et al, 2010; Tukachinsky et al, 2010; reviewed in Briscoe and Therond, 2013).

Literature References
PubMed ID Title Journal Year
20154143 Kinetics of hedgehog-dependent full-length Gli3 accumulation in primary cilia and subsequent degradation

Wen, X, Lai, CK, Evangelista, M, Hongo, JA, de Sauvage, FJ, Scales, SJ

Mol. Cell. Biol. 2010
19996169 Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus

Kim, J, Kato, M, Beachy, PA

Proc. Natl. Acad. Sci. U.S.A. 2009
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Joyner, AL, Wang, B

Mol. Cell. Biol. 2006
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Briscoe, J, Thérond, PP

Nat. Rev. Mol. Cell Biol. 2013
20360384 The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

Humke, EW, Dorn, KV, Milenkovic, L, Scott, MP, Rohatgi, R

Genes Dev. 2010
20956384 A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes

Tukachinsky, H, Lopez, LV, Salic, A

J. Cell Biol. 2010
Participants
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Orthologous Events
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