ULK3:SUFU dissociates

Stable Identifier
Reaction [dissociation]
Homo sapiens
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ULK3 is a serine-threonine kinase that was identified as a positive regulator of Hh signaling that regulates GLI activity by phosphorylating the full-length form (Maloverjan et al, 2010a). In the absence of Hh ligand, ULK3 forms a complex with SUFU that restricts its kinase activity (Maloverjan et al, 2010b). Upon Hh stimulation, the ULK3:SUFU complex dissociates, allowing ULK3 to phosphorylate the full-length GLI proteins and promoting their activation and nuclear localization (Maloverjan et al, 2010a; Maloverjan et al, 2010b). ULK3 is related by sequence to the vertebrate kinase STK36, homologue to Drosophila Fused (Fu). While Fu plays a critical role in propagating Hh signal and is part of the Hedgehog signaling complex (HSC), STK36 is not required for Hh signaling in vertebrate cells but instead contributes to the formation of motile cilia (Wilson et al, 2009; reviewed in Briscoe and Therond, 2013; Maloverjan and Piirsoo, 2012).
Literature References
PubMed ID Title Journal Year
22391301 Mammalian homologues of Drosophila fused kinase

Piirsoo, M, Maloverjan, A

Vitam. Horm. 2012
19305393 Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

Huang, J, Chen, JN, Chuang, PT, Gacayan, R, Yang, JH, Nguyen, CT, Wilson, CW, Chen, MH

Nature 2009
20643644 Dual function of UNC-51-like kinase 3 (Ulk3) in the Sonic hedgehog signaling pathway

Kogerman, P, Kasak, L, Piirsoo, M, Maloverjan, A, Østerlund, T, Peil, L

J. Biol. Chem. 2010
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Thérond, PP, Briscoe, J

Nat. Rev. Mol. Cell Biol. 2013
19878745 Identification of a novel serine/threonine kinase ULK3 as a positive regulator of Hedgehog pathway

Kogerman, P, Osterlund, T, Piirsoo, M, Maloverjan, A, Michelson, P

Exp. Cell Res. 2010
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