SLC26A4 transports I- from cytosol to extracellular region

Stable Identifier
R-HSA-5627802
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC26 members A3, 4 and 6 are able to exchange chloride for bicarbonate. SLC26A4 (Pendrin) can also mediate the efflux of iodide (I-) from the apical membranes of thyroid and inner ear cells. SLC26A4 is highly expressed in the adult thyroid and its activity is necessary for production of thyroid hormone (Dossena et al. 2006). Mutations in this gene are associated with Pendred syndrome, an autosomal-recessive disease which is the most common form of syndromic deafness and associated goitre.

Literature References
PubMed ID Title Journal Year
16914891 Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity

Dossena, S, Rodighiero, S, Vezzoli, V, Bazzini, C, Sironi, C, Meyer, G, Fürst, J, Ritter, M, Garavaglia, ML, Fugazzola, L, Persani, L, Zorowka, P, Storelli, C, Beck-Peccoz, P, Bottá, G, Paulmichl, M

Cell. Physiol. Biochem. 2006
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
iodide transmembrane transporter activity of SLC26A4 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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