Reactome | SLC26A4 exports I- to follicular lumen

SLC26A4 exports I- to follicular lumen

Stable Identifier

R-HSA-5627802

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

SLC26A4 transports I- from cytosol to extracellular region

ReviewStatus

5/5

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SLC26A4 (Pendrin, PDS) can mediate the efflux of iodide (I-) from the apical membranes of thyroid cells in exchange for a chloride (Cl-) ion, a function demonstrated in human HEK293 and monkey COS-7 cells (Yoshida et al., 2004; Dossena et al. 2006). SLC26A4 is highly expressed in the adult thyroid and its activity is necessary for production of thyroid hormone (Yoshida et al., 2004; Honda & Griffith, 2022). SLC26A4 is also expressed in the inner ear (Dossena et al. 2006; Honda & Griffith, 2022). Mutations in this gene are associated with Pendred syndrome, an autosomal-recessive disease which is one of the most common forms of syndromic deafness and associated goiter (Dossena et al. 2006; reviewed in Honda & Griffith, 2022).

Literature References

PubMed ID	Title	Journal	Year
15155570	Mechanism of iodide/chloride exchange by pendrin Yoshida, A, Hisatome, I, Taniguchi, S, Sasaki, N, Yamamoto, Y, Miake, J, Fukui, H, Shimizu, H, Okamura, T, Okura, T, Igawa, O, Shigemasa, C, Green, ED, Kohn, LD, Suzuki, K	Endocrinology	2004
24051746	Use of SLC26A4 mutation testing for unilateral enlargement of the vestibular aqueduct Chattaraj, P, Reimold, FR, Muskett, JA, Shmukler, BE, Chien, WW, Madeo, AC, Pryor, SP, Zalewski, CK, Butman, JA, Brewer, CC, Kenna, MA, Alper, SL, Griffith, AJ	JAMA Otolaryngol Head Neck Surg	2013
34345941	Genetic architecture and phenotypic landscape of SLC26A4-related hearing loss Honda, K, Griffith, AJ	Hum Genet	2022
16914891	Fast fluorometric method for measuring pendrin (SLC26A4) Cl-/I- transport activity Dossena, S, Rodighiero, S, Vezzoli, V, Bazzini, C, Sironi, C, Meyer, G, Fürst, J, Ritter, M, Garavaglia, ML, Fugazzola, L, Persani, L, Zorowka, P, Storelli, C, Beck-Peccoz, P, Bottá, G, Paulmichl, M	Cell. Physiol. Biochem.	2006