PDE6D binds INPP5E

Stable Identifier
R-HSA-5624956
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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The inositol polyphosphate phosphatase INPP5E is a ciliary localized peripheral membrane protein with a CaaX prenylation motif in its C-terminus (Jacoby et al, 2009; Bielas et al, 2009; Humbert et al, 2012). This motif is downstream of the ciliary targeting sequence and prenylation is not required for the ciliary localization of INPP5E. The CaaX motif is required for the interaction between INPP5E and the phosphodiesterase PDE6D, and PDE6D is required for the ciliary localization of full length INPP5E but not a truncated solubilized form. These data suggest that PDE6D may play a role in extracting prenylated INPP5E from a donor membrane prior to ciliary targeting (Humbert et al, 2012).

Literature References
PubMed ID Title Journal Year
23150559 ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

Humbert, MC, Weihbrecht, K, Searby, CC, Li, Y, Pope, RM, Sheffield, VC, Seo, S

Proc. Natl. Acad. Sci. U.S.A. 2012
19668215 INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

Jacoby, M, Cox, JJ, Gayral, S, Hampshire, DJ, Ayub, M, Blockmans, M, Pernot, E, Kisseleva, MV, Compère, P, Schiffmann, SN, Gergely, F, Riley, JH, Pérez-Morga, D, Woods, CG, Schurmans, S

Nat. Genet. 2009
19668216 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies

Bielas, SL, Silhavy, JL, Brancati, F, Kisseleva, MV, Al-Gazali, L, Sztriha, L, Bayoumi, RA, Zaki, MS, Abdel-Aleem, A, Rosti, RO, Kayserili, H, Swistun, D, Scott, LC, Bertini, E, Boltshauser, E, Fazzi, E, Travaglini, L, Field, SJ, Gayral, S, Jacoby, M, Schurmans, S, Dallapiccola, B, Majerus, PW, Valente, EM, Gleeson, JG

Nat Genet 2009
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