Reactome | PDE6D binds INPP5E

PDE6D binds INPP5E

Stable Identifier

R-HSA-5624956

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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The inositol polyphosphate phosphatase INPP5E is a ciliary localized peripheral membrane protein with a CaaX prenylation motif in its C-terminus (Jacoby et al, 2009; Bielas et al, 2009; Humbert et al, 2012). This motif is downstream of the ciliary targeting sequence and prenylation is not required for the ciliary localization of INPP5E. The CaaX motif is required for the interaction between INPP5E and the phosphodiesterase PDE6D, and PDE6D is required for the ciliary localization of full length INPP5E but not a truncated solubilized form. These data suggest that PDE6D may play a role in extracting prenylated INPP5E from a donor membrane prior to ciliary targeting (Humbert et al, 2012).

Literature References

PubMed ID	Title	Journal	Year
19668215	INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse Jacoby, M, Cox, JJ, Gayral, S, Hampshire, DJ, Ayub, M, Blockmans, M, Pernot, E, Kisseleva, MV, Compère, P, Schiffmann, SN, Gergely, F, Riley, JH, Pérez-Morga, D, Woods, CG, Schurmans, S	Nat. Genet.	2009
23150559	ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting Humbert, MC, Weihbrecht, K, Searby, CC, Li, Y, Pope, RM, Sheffield, VC, Seo, S	Proc. Natl. Acad. Sci. U.S.A.	2012
19668216	Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies Bielas, SL, Silhavy, JL, Brancati, F, Kisseleva, MV, Al-Gazali, L, Sztriha, L, Bayoumi, RA, Zaki, MS, Abdel-Aleem, A, Rosti, RO, Kayserili, H, Swistun, D, Scott, LC, Bertini, E, Boltshauser, E, Fazzi, E, Travaglini, L, Field, SJ, Gayral, S, Jacoby, M, Schurmans, S, Dallapiccola, B, Majerus, PW, Valente, EM, Gleeson, JG	Nat Genet	2009