ARL13B binds INPP5E

Stable Identifier
R-HSA-5624953
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cilium
ReviewStatus
5/5
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ARL13B binds INPP5E
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The small GTPase ARL13B is required for the ciliary localization of INPP5E. ARL13B binds directly to INPP5E and is thought to displace PDE6D from the complex (Humbert et al, 2012).

Literature References
PubMed ID Title Journal Year
23150559 ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting

Seo, S, Searby, CC, Li, Y, Pope, RM, Sheffield, VC, Humbert, MC, Weihbrecht, K

Proc. Natl. Acad. Sci. U.S.A. 2012
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Orthologous Events
ARL13B binds INPP5E (Bos taurus)
ARL13B binds INPP5E (Canis familiaris)
ARL13B binds INPP5E (Danio rerio)
ARL13B binds INPP5E (Gallus gallus)
ARL13B binds INPP5E (Mus musculus)
ARL13B binds INPP5E (Rattus norvegicus)
ARL13B binds INPP5E (Sus scrofa)
ARL13B binds INPP5E (Xenopus tropicalis)
Authored
Rothfels, K  (2014-09-19)
Reviewed
Lorentzen, E  (2014-11-10)
Goncalves, J  (2014-11-14)
Created
Rothfels, K  (2014-09-30)
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