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ARL13B binds INPP5E
Stable Identifier
R-HSA-5624953
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cilium
ReviewStatus
5/5
Locations in the PathwayBrowser
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Organelle biogenesis and maintenance (Homo sapiens)
Cilium Assembly (Homo sapiens)
Cargo trafficking to the periciliary membrane (Homo sapiens)
ARL13B-mediated ciliary trafficking of INPP5E (Homo sapiens)
ARL13B binds INPP5E (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The small GTPase ARL13B is required for the ciliary localization of INPP5E. ARL13B binds directly to INPP5E and is thought to displace PDE6D from the complex (Humbert et al, 2012).
Literature References
PubMed ID
Title
Journal
Year
23150559
ARL13B, PDE6D, and CEP164 form a functional network for INPP5E ciliary targeting
Seo, S
,
Searby, CC
,
Li, Y
,
Pope, RM
,
Sheffield, VC
,
Humbert, MC
,
Weihbrecht, K
Proc. Natl. Acad. Sci. U.S.A.
2012
Participants
Input
ARL13B [cilium]
(Homo sapiens)
PDE6D:INPP5E [cilium]
(Homo sapiens)
Output
ARL13B:INPP5E:PDE6D [cilium]
(Homo sapiens)
Participates
as an event of
ARL13B-mediated ciliary trafficking of INPP5E (Homo sapiens)
Orthologous Events
ARL13B binds INPP5E (Bos taurus)
ARL13B binds INPP5E (Canis familiaris)
ARL13B binds INPP5E (Gallus gallus)
ARL13B binds INPP5E (Mus musculus)
ARL13B binds INPP5E (Rattus norvegicus)
ARL13B binds INPP5E (Sus scrofa)
Authored
Rothfels, K (2014-09-19)
Reviewed
Lorentzen, E (2014-11-10)
Goncalves, J (2014-11-14)
Created
Rothfels, K (2014-09-30)
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