SYK autophosphorylates

Stable Identifier
R-HSA-5621370
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SYK can autophosphorylate and autophosphorylation increases its activity. It is more readily activated by autophosphorylation although it is rapidly activated by Src family kinases. SYK has multiple sites of phosphorylation which both regulate its activity and serve as docking sites for other proteins (Sada et al. 2001). Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997).

Literature References
PubMed ID Title Journal Year
18818202 Molecular mechanism of the Syk activation switch

Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM

J Biol Chem 2008
9042338 Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk

Furlong, MT, Mahrenholz, AM, Kim, KH, Ashendel, CL, Harrison, ML, Geahlen, RL

Biochim Biophys Acta 1997
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Created