Reactome | SYK autophosphorylates

SYK autophosphorylates

Stable Identifier

R-HSA-5621370

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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SYK can autophosphorylate and autophosphorylation increases its activity. It is more readily activated by autophosphorylation although it is rapidly activated by Src family kinases. SYK has multiple sites of phosphorylation which both regulate its activity and serve as docking sites for other proteins (Sada et al. 2001). Some of these sites include Y131 of interdomain A, Y323, Y348, and Y352 of interdomain B, and Y525 and Y526 within the activation loop of the kinase domain and Y630 in the C-terminus (Zhang et al. 2002, Lupher et al. 1998, Furlong et al. 1997).

Literature References

PubMed ID	Title	Journal	Year
9042338	Identification of the major sites of autophosphorylation of the murine protein-tyrosine kinase Syk Furlong, MT, Mahrenholz, AM, Kim, KH, Ashendel, CL, Harrison, ML, Geahlen, RL	Biochim Biophys Acta	1997
18818202	Molecular mechanism of the Syk activation switch Tsang, E, Giannetti, AM, Shaw, D, Dinh, M, Tse, JK, Gandhi, S, Ho, H, Wang, S, Papp, E, Bradshaw, JM	J Biol Chem	2008