Dectin-2 family

Stable Identifier
Homo sapiens
Related Species
Human immunodeficiency virus 1, Hepatitis C virus genotype 2a
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Dendritic cell-associated C-type lectin-2 (Dectin-2) family of C-type lectin receptors (CLRs) includes Dectin-2 (CLEC6A), blood dendritic antigen 2 (BDCA2/CLEC4C), macrophage C-type lectin (MCL/CLEC4D), Dendritic cell immunoreceptor (DCIR/CLEC4A) and macrophage inducible C-type lectin (Mincle/CLEC4E). These receptors possesses a single extracellular conserved C-type lectin domain (CTLD) with a short cytoplasmic tail that induces intracellular signalling indirectly by binding with the FCERG (High affinity immunoglobulin epsilon receptor subunit gamma) except for DCIR that has a longer cytoplasmic tail with an integral inhibitory signalling motif (Graham & Brown. 2009, Kerschera et al. 2013). CLEC6A (Dectin-2) binds to high mannose containing pathogen-associated molecular patterns (PAMPs) expressed by fungal hyphae, and CLEC4E (mincle) binds to alpha-mannaosyl PAMPs on fungal, mycobacterial and necrotic cell ligands. Both signaling pathways lead to Toll-like receptor (TLR)-independent production of cytokines such as tumor necrosis factor (TNF) and interleukin 6 (IL6). Similarities with Dectin-1 (CLC7A) signaling pathway suggests that both these CLRs couple SYK activation to NF-kB activation using a complex involving CARD9, BCL10 and MALT1 (Geijtenbeek & Gringhuis 2009).

Literature References
PubMed ID Title Journal Year
19521399 Signalling through C-type lectin receptors: shaping immune responses

Geijtenbeek, TB, Gringhuis, SI

Nat. Rev. Immunol. 2009
23606632 The Dectin-2 family of C-type lectin-like receptors: an update

Kerscher, B, Willment, JA, Brown, GD

Int. Immunol. 2013
19665392 The Dectin-2 family of C-type lectins in immunity and homeostasis

Graham, LM, Brown, GD

Cytokine 2009
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