HOXA2 gene is transcribed

Stable Identifier
R-HSA-5617483
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
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HOXA2 gene is transcribed
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The HOXA2 is transcribed to yield mRNA (in carcinoma cells, Yates et al. 2010). In mouse embryos Hoxa2 mRNA is observed in rhombomere 2 and caudally through posterior hindbrain, spinal cord, larynx, lungs, vertebrae, sternum, and intestine. Hoxa2 mRNA is a target of microRNA miR-3960 in differentiating mouse osteoblasts.

Literature References
PubMed ID Title Journal Year
20085832 Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8

Thompson, BA, Yates, JA, Bochar, DA, Menon, T

FEBS Lett. 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
HOXB1:PBX1:PKNOX1 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
HOXB1:PBX1:PKNOX1 [nucleoplasm]
MLL2,3 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Regulator
EGR2 at active HOXA2 chromatin [nucleoplasm] (Homo sapiens)
Active Unit
EGR2 [nucleoplasm]
MLL2,3 complex [nucleoplasm]
RNA Polymerase II holoenzyme complex (generic) [nucleoplasm]
Inferred From
Hoxa2 gene is transcribed (Mus musculus)
Authored
Rezsohazy, R  (2015-11-15)
May, B  (2014-08-08)
Reviewed
Blasi, F  (2015-05-13)
Created
May, B  (2014-08-12)
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