GLI3R translocates to the nucleus

Stable Identifier
R-HSA-5610752
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
GLI3R translocates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After processing by the proteasome, the truncated GLI3 translocates into the nucleus where it acts as the primary repressor for Hh-responsive genes (reviewed in Briscoe and Therond, 2013). Based on sequence comparisons with Ci and GLI1, GLI3 is predicted to have a bipartite NLS signal near the zinc finger domain, and import to the nucleus may be mediated by Importin alpha3, although the details remain to be worked out (reviewed in Hatayama and Aruga, 2012).
Literature References
PubMed ID Title Journal Year
22391300 Gli protein nuclear localization signal

Aruga, J, Hatayama, M

Vitam. Horm. 2012
23719536 The mechanisms of Hedgehog signalling and its roles in development and disease

Thérond, PP, Briscoe, J

Nat. Rev. Mol. Cell Biol. 2013
Participants
Input
Output
Participates
as an event of
Orthologous Events
GLI3R translocates to the nucleus (Bos taurus)
GLI3R translocates to the nucleus (Canis familiaris)
GLI3R translocates to the nucleus (Danio rerio)
GLI3R translocates to the nucleus (Drosophila melanogaster)
GLI3R translocates to the nucleus (Gallus gallus)
GLI3R translocates to the nucleus (Mus musculus)
GLI3R translocates to the nucleus (Rattus norvegicus)
GLI3R translocates to the nucleus (Sus scrofa)
GLI3R translocates to the nucleus (Xenopus tropicalis)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
Cite Us!