GSK3 phosphorylates p-GLI2

Stable Identifier
R-HSA-5610730
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ciliary base
ReviewStatus
5/5
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GSK3 phosphorylates p-GLI2
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Like GLI3, GLI2 has putative GSK3 sites that contribute to the proteasome-dependent degradation of the protein in the absence of Hh signal. Deletion of the GSK3 phosphorylation sites abrogates the interaction with beta-TrCP, stabilizes GLI2 protein and increases the expression of a GLI-dependent reporter, consistent with a role for GSK3 in promoting GLI2 degradation (Pan et al, 2006).
Literature References
PubMed ID Title Journal Year
16611981 Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation

Pan, Y, Bai, CB, Wang, B, Joyner, AL

Mol. Cell. Biol. 2006
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Output
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Catalyst Activity

protein serine/threonine kinase activity of GSK3B [cytosol]

Physical Entity
GSK3B [cytosol] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Inferred From
GSK3 phosphorylates p-Gli2 (Mus musculus)
Authored
Rothfels, K  (2014-05-07)
Reviewed
Liu, Y C  (2014-08-01)
Created
Rothfels, K  (2014-07-23)
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