Reactome | The IFT-A complex recruits TULP3

The IFT-A complex recruits TULP3

Stable Identifier

R-HSA-5610726

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cilium

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TULP3 is recruited to the primary cilium through a direct interaction with the retrograde transport IFT-A complex and with membrane phosphoinositides (Santagata et al, 2001; Mukhopadhyay et al, 2010; Qin et al, 2011; reviewed in Mukhopadhyay and Rohatgi, 2014). TULP3 facilitates GLI processing by recruiting the GPCR GPR161, which in turn activates PKA by increasing cAMP levels in a G alpha s-dependent manner (Mukhopadhyay et al, 2013, reviewed in Hwang and Mukhopadhyay, 2014; Pal and Mukhopadhyay, 2014).

Literature References

PubMed ID	Title	Journal	Year
21209331	Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components Qin, J, Lin, Y, Norman, RX, Ko, HW, Eggenschwiler, JT	Proc. Natl. Acad. Sci. U.S.A.	2011
24863049	Primary cilium and sonic hedgehog signaling during neural tube patterning: Role of GPCRs and second messengers Pal, K, Mukhopadhyay, S	Dev Neurobiol	2014
23332756	The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling Mukhopadhyay, S, Wen, X, Ratti, N, Loktev, A, Rangell, L, Scales, SJ, Jackson, PK	Cell	2013
20889716	TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia Mukhopadhyay, S, Wen, X, Chih, B, Nelson, CD, Lane, WS, Scales, SJ, Jackson, PK	Genes Dev.	2010
11375483	G-protein signaling through tubby proteins Santagata, S, Boggon, TJ, Baird, CL, Gomez, CA, Zhao, J, Shan, WS, Myszka, DG, Shapiro, L	Science	2001
24917297	G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning Hwang, SH, Mukhopadhyay, S	Birth Defects Res. Part A Clin. Mol. Teratol.	2014
24845016	G-protein-coupled receptors, Hedgehog signaling and primary cilia Mukhopadhyay, S, Rohatgi, R	Semin. Cell Dev. Biol.	2014