The IFT-A complex recruits TULP3

Stable Identifier
Reaction [binding]
Homo sapiens
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TULP3 is recruited to the primary cilium through a direct interaction with the retrograde transport IFT-A complex and with membrane phosphoinositides (Santagata et al, 2001; Mukhopadhyay et al, 2010; Qin et al, 2011; reviewed in Mukhopadhyay and Rohatgi, 2014). TULP3 facilitates GLI processing by recruiting the GPCR GPR161, which in turn activates PKA by increasing cAMP levels in a G alpha s-dependent manner (Mukhopadhyay et al, 2013, reviewed in Hwang and Mukhopadhyay, 2014; Pal and Mukhopadhyay, 2014).

Literature References
PubMed ID Title Journal Year
21209331 Intraflagellar transport protein 122 antagonizes Sonic Hedgehog signaling and controls ciliary localization of pathway components

Ko, HW, Lin, Y, Qin, J, Eggenschwiler, JT, Norman, RX

Proc. Natl. Acad. Sci. U.S.A. 2011
24863049 Primary cilium and sonic hedgehog signaling during neural tube patterning: Role of GPCRs and second messengers

Pal, K, Mukhopadhyay, S

Dev Neurobiol 2014
23332756 The ciliary G-protein-coupled receptor Gpr161 negatively regulates the Sonic hedgehog pathway via cAMP signaling

Scales, SJ, Wen, X, Rangell, L, Jackson, PK, Loktev, A, Mukhopadhyay, S, Ratti, N

Cell 2013
20889716 TULP3 bridges the IFT-A complex and membrane phosphoinositides to promote trafficking of G protein-coupled receptors into primary cilia

Lane, WS, Scales, SJ, Wen, X, Chih, B, Jackson, PK, Nelson, CD, Mukhopadhyay, S

Genes Dev. 2010
11375483 G-protein signaling through tubby proteins

Myszka, DG, Gomez, CA, Shan, WS, Boggon, TJ, Santagata, S, Zhao, J, Baird, CL, Shapiro, L

Science 2001
24917297 G-protein-coupled receptors and localized signaling in the primary cilium during ventral neural tube patterning

Hwang, SH, Mukhopadhyay, S

Birth Defects Res. Part A Clin. Mol. Teratol. 2014
24845016 G-protein-coupled receptors, Hedgehog signaling and primary cilia

Rohatgi, R, Mukhopadhyay, S

Semin. Cell Dev. Biol. 2014
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