Reactome | CK1 phosphorylates p-GLI2

CK1 phosphorylates p-GLI2

Stable Identifier

R-HSA-5610718

Type

Reaction [transition]

Species

Homo sapiens

Compartment

ciliary base

ReviewStatus

5/5

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Phosphorylation by PKA primes GLI2 for subsequent phosphorylation at adjacent CK sites (Pan et al, 2006; Pan and Wang, 2007).

Literature References

PubMed ID	Title	Journal	Year
17283082	A novel protein-processing domain in Gli2 and Gli3 differentially blocks complete protein degradation by the proteasome Pan, Y, Wang, B	J. Biol. Chem.	2007
16611981	Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Pan, Y, Bai, CB, Joyner, AL, Wang, B	Mol. Cell. Biol.	2006

Participants

Input

Output

Participates

as an event of

Degradation of GLI2 by the proteasome (Homo sapiens)

Catalyst Activity

protein serine/threonine kinase activity of CSNK1A1 [cytosol]

Physical Entity

CSNK1A1 [cytosol] (Homo sapiens)

Activity

protein serine/threonine kinase activity (GO:0004674)

Inferred From

CK1 phosphorylates p-Gli2 (Mus musculus)

Authored

Rothfels, K (2014-05-07)

Reviewed

Liu, Y C (2014-08-01)

Created

Rothfels, K (2014-07-23)

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