Reactome | CARD9 oligomerizes

CARD9 oligomerizes

Stable Identifier

R-HSA-5607753

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

ReviewStatus

5/5

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Activated CARD9 localised in lipid rafts may self-associate with other CARD9 molecules (oligomerization). Residues 140-420 of CARD9 contain heptad repeats characteristic of coiled-coil structures that function in protein oligomerization (Bertin et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
11053425	CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B Alnemri, ES, Du, MQ, Robison, KE, Srinivasula, SM, DiStefano, PS, Dyer, MJ, Guo, Y, Bertin, J, Merriam, S, Poyet, JL, Jacobson, MD, Wang, L	J. Biol. Chem.	2000
19359218	CARD9 versus CARMA1 in innate and adaptive immunity Hara, H, Saito, T	Trends Immunol.	2009