CARD9 oligomerizes

Stable Identifier
R-HSA-5607753
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CARD9 oligomerizes
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Activated CARD9 localised in lipid rafts may self-associate with other CARD9 molecules (oligomerization). Residues 140-420 of CARD9 contain heptad repeats characteristic of coiled-coil structures that function in protein oligomerization (Bertin et al. 2000).

Literature References
PubMed ID Title Journal Year
19359218 CARD9 versus CARMA1 in innate and adaptive immunity

Hara, H, Saito, T

Trends Immunol. 2009
11053425 CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B

Bertin, J, Guo, Y, Wang, L, Srinivasula, SM, Jacobson, MD, Poyet, JL, Merriam, S, Du, MQ, Dyer, MJ, Robison, KE, DiStefano, PS, Alnemri, ES

J. Biol. Chem. 2000
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
CARD9 oligomerizes (Bos taurus)
CARD9 oligomerizes (Canis familiaris)
CARD9 oligomerizes (Danio rerio)
CARD9 oligomerizes (Gallus gallus)
CARD9 oligomerizes (Mus musculus)
CARD9 oligomerizes (Rattus norvegicus)
CARD9 oligomerizes (Sus scrofa)
CARD9 oligomerizes (Xenopus tropicalis)
Authored
Garapati, P V  (2014-07-14)
Reviewed
Geijtenbeek, TB  (2014-09-02)
Created
Garapati, P V  (2014-07-14)