After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL2 (HILI, homolog of MILI in mouse), likely in a complex with TDRD1, TDRD12, DDX4 (MVH), ASZ (GASZ), and MOV10L, all of which are required for wild-type levels of piRNA biogenesis. Binding by PIWIL2 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.
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