Complexed PIWIL2 binds pre-piRNA

Stable Identifier
R-HSA-5603062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Complexed PIWIL2 binds pre-piRNA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL2 (HILI, homolog of MILI in mouse), likely in a complex with TDRD1, TDRD12, DDX4 (MVH), ASZ (GASZ), and MOV10L, all of which are required for wild-type levels of piRNA biogenesis. Binding by PIWIL2 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.
Participants
Input
Output
Participates
as an event of
Inferred From
Complexed Piwil2 binds pre-piRNA (Mus musculus)
Authored
May, B  (2014-06-14)
Reviewed
Saito, K  (2014-10-25)
Created
May, B  (2014-06-27)
Cite Us!