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Complexed PIWIL2 binds pre-piRNA
Stable Identifier
R-HSA-5603062
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Gene expression (Transcription) (Homo sapiens)
Gene Silencing by RNA (Homo sapiens)
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Complexed PIWIL2 binds pre-piRNA (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
After cleavage by PLD6 at the 5' end, the pre-piRNA is bound by PIWIL2 (HILI, homolog of MILI in mouse), likely in a complex with TDRD1, TDRD12, DDX4 (MVH), ASZ (GASZ), and MOV10L, all of which are required for wild-type levels of piRNA biogenesis. Binding by PIWIL2 is believed to be selective for pre-piRNAs that have uracil residues at their 5' ends.
Participants
Input
6xMeR-PIWIL2:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol]
(Homo sapiens)
pre-piRNA [cytosol]
(Homo sapiens)
Output
6xMeR-PIWIL2:pre-piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1 [cytosol]
(Homo sapiens)
Participates
as an event of
PIWI-interacting RNA (piRNA) biogenesis (Homo sapiens)
Inferred From
Complexed Piwil2 binds pre-piRNA (Mus musculus)
Authored
May, B (2014-06-14)
Reviewed
Saito, K (2014-10-25)
Created
May, B (2014-06-27)
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