Expression of CCRN4L (NOCTURNIN)

Stable Identifier
R-HSA-549424
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
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Expression of CCRN4L (NOCTURNIN)
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The NOCTURNIN gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The NOCTURNIN gene shows circadian expression because the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the NOCTURNIN promoter and activates transcription.

The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the promoter of the NOCTURNIN gene and activates transcription of NOCTURNIN. NPAS2 is predicted to act redundantly with CLOCK.

Literature References
PubMed ID Title Journal Year
18587630 CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter

Zhang, Y, Yue, J, Peng, X, Hao, W, Yuan, J, Li, R, Qiang, B, Cao, JM, Ding, JM, Zhou, L

Mol Cell Biochem 2008
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Output
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This event is regulated
Positively by
Regulator
p-BMAL1:p-CLOCK,NPAS2:CCRN4L gene [nucleoplasm] (Homo sapiens)
Authored
May, B  (2010-03-19)
Reviewed
Delaunay, F  (2010-06-23)
Hirota, T  (2010-06-23)
Kay, SA  (2010-06-23)
Albrecht, U  (2010-06-23)
D'Eustachio, P  (2009-05-27)
Created
May, B  (2010-03-21)
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