Expression of CCRN4L (NOCTURNIN)

Stable Identifier
R-HSA-549424
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The NOCTURNIN gene is transcribed to yield mRNA and the mRNA is translated to yield protein. The NOCTURNIN gene shows circadian expression because the BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the NOCTURNIN promoter and activates transcription.

Literature References
PubMed ID Title Journal Year
18587630 CLOCK/BMAL1 regulates human nocturnin transcription through binding to the E-box of nocturnin promoter

Li, R, Yue, J, Zhang, Y, Zhou, L, Hao, W, Yuan, J, Qiang, B, Ding, JM, Peng, X, Cao, JM

Mol Cell Biochem 2008
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Summation

The phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) heterodimer binds an E-box element in the promoter of the NOCTURNIN gene and activates transcription of NOCTURNIN. NPAS2 is predicted to act redundantly with CLOCK.

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