Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
SLC22A1 [plasma membrane]
Stable Identifier
R-HSA-549126
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OCT1, Solute carrier family 22 member 1, S22A1_HUMAN, Organic cation transporter 1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Abacavir transport and metabolism (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Noradrenaline clearance from the synaptic cleft (Homo sapiens)
OCT2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
OCT2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
OCT2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT1 transports organic cations into hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT1 transports organic cations out of hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
OCT2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
OCT2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15245 SLC22A1
Gene Names
SLC22A1, OCT1
Chain
chain:1-554
Reference Genes
BioGPS Gene:6580 SLC22A1
COSMIC (genes):SLC22A1 SLC22A1
CTD Gene:6580 SLC22A1
dbSNP Gene:6580 SLC22A1
ENSEMBL:ENSG00000175003 SLC22A1
ENSEMBL_homo_sapiens_GENE:ENSG00000175003 SLC22A1
HGNC:10963 SLC22A1
KEGG Gene (Homo sapiens):6580 SLC22A1
Monarch:6580 SLC22A1
NCBI Gene:6580 SLC22A1
OMIM:602607 SLC22A1
UCSC:O15245 SLC22A1
Reference Transcript
RefSeq:XM_006715552.1 SLC22A1
RefSeq:NM_003057.2 SLC22A1
RefSeq:NM_153187.1 SLC22A1
Other Identifiers
0002100458
0005900711
11731577_a_at
17014423
207201_s_at
2934452
2934453
2934459
2934460
2934461
2934464
2934466
2934467
2934468
2934469
2934471
2934473
2934474
2934476
2934477
2934478
2934479
29846
35113_at
6580
8123232
A_23_P145569
AAB67703
AAI26365
AJ243995
AJ243996
AJ243998
AJ243999
AJ244000
AJ245460
AJ276051
AJ276052
AJ276053
AK289887
AL353625
BAF82576
BC126364
CAA66977
CAB95971
CCDS5274
CCDS5275
ENSG00000175003
ENSP00000318103
ENSP00000355930
ENSP00000409557
ENSP00000439274
ENSP00000495844
ENST00000324965
ENST00000366963
ENST00000457470
ENST00000460902
ENST00000642587
EntrezGene:6580
F5GY86
F5H5P3
g4506998_3p_a_at
g4506998_3p_s_at
GE60208
GO:0003674
GO:0005215
GO:0005277
GO:0005330
GO:0005334
GO:0005515
GO:0005575
GO:0005623
GO:0005886
GO:0005887
GO:0006810
GO:0006811
GO:0006812
GO:0006836
GO:0006855
GO:0008150
GO:0008504
GO:0008513
GO:0010248
GO:0015101
GO:0015651
GO:0015695
GO:0015697
GO:0015844
GO:0015872
GO:0015874
GO:0016020
GO:0016021
GO:0016323
GO:0022607
GO:0022857
GO:0042802
GO:0042803
GO:0048241
GO:0051260
GO:0051620
GO:0055085
GO:0065003
GO:0072488
GO:0090494
GO:1901374
HGNC:10963
HPA029846
ILMN_1675597
ILMN_1715742
IPR004749
IPR005828
IPR005829
IPR020846
IPR036259
MIM:602607
NM_003057
NM_153187
NP_003048
NP_694857
PF00083
PH_hs_0006447
SLC22A1
SLC22A1-201
SLC22A1-202
SLC22A1-203
SLC22A1-204
SLC22A1-208
TC06001154.hg
U77086
uc003qtc.4
uc003qtd.4
uc063sqo.1
uc063sqp.1
UPI0000070FB1
UPI0000141519
UPI0001AE72FA
UPI0001E88ED2
X98332
XM_005267102
XM_005267103
XM_005267104
XM_005267105
XM_006715552
XM_011536074
XP_005267159
XP_005267160
XP_005267161
XP_005267162
XP_006715615
XP_011534376
Participant Of
hasCandidate
OCT2 [plasma membrane]
hasMember
OCT1 [plasma membrane]
SLC22A1,2,3 [plasma membrane]
Inferred To
Homologues of SLC22A1 [plasma membrane] (Arabidopsis thaliana)
Homologues of SLC22A1 [plasma membrane] (Drosophila melanogaster)
Homologues of SLC22A1 [plasma membrane] (Oryza sativa)
Homologues of SLC22A1 [plasma membrane] (Sus scrofa)
SLC22A1 [plasma membrane] (Arabidopsis thaliana)
SLC22A1 [plasma membrane] (Bos taurus)
SLC22A1 [plasma membrane] (Caenorhabditis elegans)
SLC22A1 [plasma membrane] (Canis familiaris)
SLC22A1 [plasma membrane] (Danio rerio)
SLC22A1 [plasma membrane] (Drosophila melanogaster)
SLC22A1 [plasma membrane] (Mus musculus)
SLC22A1 [plasma membrane] (Oryza sativa)
SLC22A1 [plasma membrane] (Rattus norvegicus)
SLC22A1 [plasma membrane] (Sus scrofa)
SLC22A1 [plasma membrane] (Xenopus tropicalis)
Cross References
RefSeq
NP_694857.1
,
XP_006715615.1
,
NP_003048.1
ZINC - Metabolites
S22A1_HUMAN
ZINC - World Drugs
S22A1_HUMAN
OpenTargets
ENSG00000175003
ZINC - FDA approved
S22A1_HUMAN
GeneCards
O15245
ZINC - Substances
S22A1_HUMAN
ZINC target
O15245
ZINC - Biogenic
S22A1_HUMAN
PRO
O15245
ZINC - Predictions - Purchasable
S22A1_HUMAN
HMDB Protein
HMDBP02574
© 2019
Reactome