Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
SLC22A1 [plasma membrane]
Stable Identifier
R-HSA-549126
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
OCT1, Solute carrier family 22 member 1, S22A1_HUMAN, Organic cation transporter 1
Locations in the PathwayBrowser
Expand all
Drug ADME (Homo sapiens)
Abacavir ADME (Homo sapiens)
Abacavir transmembrane transport (Homo sapiens)
abacavir [extracellular] => abacavir [cytosol] (Homo sapiens)
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter clearance (Homo sapiens)
Noradrenaline clearance from the synaptic cleft (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Neurotransmitter release cycle (Homo sapiens)
Norepinephrine Neurotransmitter Release Cycle (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Transport of small molecules (Homo sapiens)
SLC-mediated transmembrane transport (Homo sapiens)
Transport of bile salts and organic acids, metal ions and amine compounds (Homo sapiens)
Na+/Cl- dependent neurotransmitter transporters (Homo sapiens)
Uptake of Noradrenaline (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
Organic cation/anion/zwitterion transport (Homo sapiens)
Organic cation transport (Homo sapiens)
OCT1 transports organic cations into hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT1 transports organic cations out of hepatic cells (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular secretion of organic cations in the kidney (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
OCT2 mediates tubular uptake of organic cations in the kidney (Homo sapiens)
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
SLC22A1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15245 SLC22A1
Gene Names
SLC22A1, OCT1
Chain
chain:1-554
Reference Genes
BioGPS Gene:6580 SLC22A1
COSMIC (genes):SLC22A1 SLC22A1
CTD Gene:6580 SLC22A1
dbSNP Gene:6580 SLC22A1
ENSEMBL:ENSG00000175003 SLC22A1
HGNC:10963 SLC22A1
KEGG:hsa:6580 SLC22A1
Monarch:6580 SLC22A1
NCBI Gene:6580 SLC22A1
OMIM:602607 SLC22A1
UCSC:O15245 SLC22A1
Reference Transcript
RefSeq:NM_153187.1 SLC22A1
RefSeq:NM_003057.2 SLC22A1
RefSeq:XM_006715552.1 SLC22A1
Other Identifiers
11731577_a_at
17014423
207201_PM_s_at
207201_s_at
2934452
2934453
2934458
2934459
2934460
2934461
2934464
2934466
2934467
2934468
2934469
2934471
2934473
2934474
2934476
2934477
2934478
2934479
2934480
35113_at
6580
8123232
A_23_P145569
GE60208
GO:0003013
GO:0005215
GO:0005277
GO:0005326
GO:0005330
GO:0005334
GO:0005515
GO:0005886
GO:0006805
GO:0006811
GO:0006812
GO:0006836
GO:0006837
GO:0008504
GO:0008514
GO:0009925
GO:0010248
GO:0015101
GO:0015132
GO:0015214
GO:0015234
GO:0015489
GO:0015606
GO:0015651
GO:0015695
GO:0015697
GO:0015732
GO:0015844
GO:0015847
GO:0015848
GO:0015870
GO:0015872
GO:0015874
GO:0015888
GO:0016020
GO:0016323
GO:0016324
GO:0016328
GO:0019534
GO:0022857
GO:0042802
GO:0042908
GO:0042910
GO:0048241
GO:0048856
GO:0051610
GO:0051620
GO:0055085
GO:0071934
GO:0072237
GO:0072530
GO:0090494
GO:0098655
GO:0098754
GO:0098793
GO:0150104
GO:1901235
GO:1902270
GO:1902616
GO:1903711
GO:1990748
GO:1990962
HMNXSV003005000
ILMN_1675597
ILMN_1715742
PH_hs_0006447
TC06001154.hg
g4506998_3p_a_at
g4506998_3p_s_at
Participates
as a member of
SLC22A1,2,3 [plasma membrane] (Homo sapiens)
OCT1 [plasma membrane] (Homo sapiens)
as a candidate of
SLC22A1,SLC22A2 [plasma membrane] (Homo sapiens)
Other forms of this molecule
SLC22A1 [basolateral plasma membrane]
Inferred To
Orct [plasma membrane]
(Drosophila melanogaster)
Dmel\CG16727 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14855 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4630 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7342 [plasma membrane]
(Drosophila melanogaster)
pes-23 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG10486 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6356 [plasma membrane]
(Drosophila melanogaster)
slc22a2 [plasma membrane]
(Danio rerio)
slc22a2 [plasma membrane]
(Xenopus tropicalis)
Dmel\CG5592 [plasma membrane]
(Drosophila melanogaster)
CG6596 [plasma membrane]
(Drosophila melanogaster)
CT19169 [plasma membrane]
(Drosophila melanogaster)
CarT [plasma membrane]
(Drosophila melanogaster)
oct-2 [plasma membrane]
(Caenorhabditis elegans)
suex-2 [plasma membrane]
(Caenorhabditis elegans)
CG31530-RA [plasma membrane]
(Drosophila melanogaster)
CG8654-RA [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17752 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG7333 [plasma membrane]
(Drosophila melanogaster)
Orct2 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4465 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14857 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG4462 [plasma membrane]
(Drosophila melanogaster)
oct-1 [plasma membrane]
(Caenorhabditis elegans)
Dmel\CG7084 [plasma membrane]
(Drosophila melanogaster)
Homologues of SLC22A1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of SLC22A1 [plasma membrane]
(Drosophila melanogaster)
Balat [plasma membrane]
(Drosophila melanogaster)
Dmel\CG14856 [plasma membrane]
(Drosophila melanogaster)
Dmel\CG6231 [plasma membrane]
(Drosophila melanogaster)
SLC22A [plasma membrane]
(Drosophila melanogaster)
Dmel\CG17751 [plasma membrane]
(Drosophila melanogaster)
Slc22a1 [plasma membrane]
(Mus musculus)
Slc22a1 [plasma membrane]
(Rattus norvegicus)
Dmel\CG7458 [plasma membrane]
(Drosophila melanogaster)
SLC22A1 [plasma membrane]
(Bos taurus)
SLC22A1 [plasma membrane]
(Caenorhabditis elegans)
SLC22A1 [plasma membrane]
(Canis familiaris)
SLC22A1 [plasma membrane]
(Gallus gallus)
SLC22A1 [plasma membrane]
(Sus scrofa)
Dmel\CG4459 [plasma membrane]
(Drosophila melanogaster)
Cross References
Guide to Pharmacology - Targets
1019
OpenTargets
ENSG00000175003
ENSEMBL
ENSP00000409557
,
ENST00000366963
,
ENST00000460902
,
ENSP00000439274
,
ENSG00000175003
,
ENSP00000355930
,
ENSP00000318103
,
ENST00000457470
,
ENST00000324965
ZINC - FDA approved
S22A1_HUMAN
ZINC - Substances
S22A1_HUMAN
ZINC - Biogenic
S22A1_HUMAN
ZINC target
O15245
PRO
O15245
GlyGen
O15245
PDB
8JTW
,
8JTY
,
8SC6
,
8SC4
,
8JU0
,
8ET6
,
8JTV
,
8JTX
,
8SC3
,
8JTS
,
8JTZ
,
8ET7
,
8ET8
,
8SC1
,
8JTT
,
8SC2
ZINC - Investigational
S22A1_HUMAN
ZINC - Metabolites
S22A1_HUMAN
HPA
ENSG00000175003-SLC22A1
GeneCards
SLC22A1
Pharos - Targets
O15245
ZINC - Predictions - Purchasable
S22A1_HUMAN
HMDB Protein
HMDBP02574
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96G23 CERS2
1
CERS2 [endoplasmic reticulum membrane]
(R-HSA-428171)
0.646
3
UniProt:Q9BZL3 SMIM3
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text